Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes
SR Hinson, MF Romero… - Proceedings of the …, 2012 - National Acad Sciences
… of nonneural (HEK293) cells (4). NMO-IgG also causes AQP4 to redistribute in the plasma
… This article reports two novel outcomes of NMO-IgG binding to the AQP4 ectodomain in …
… This article reports two novel outcomes of NMO-IgG binding to the AQP4 ectodomain in …
Aquaporin 4: a player in cerebral edema and neuroinflammation
… The assemblage of four molecules of AQP4 forms a central pore, through which water, …
associated with increased AQP4 [4]. These changes may contribute to a worse outcome in aged …
associated with increased AQP4 [4]. These changes may contribute to a worse outcome in aged …
The aquaporin-4 water channel as a potential drug target in neurological disorders
AS Verkman, AJ Smith, P Phuan… - Expert opinion on …, 2017 - Taylor & Francis
… outcome in AQP4 null mice in a stroke model [Citation25]. AQP4 null mice also showed
improved survival and outcome … is AQP4-IgG binding to astrocyte AQP4, a blocking molecule …
improved survival and outcome … is AQP4-IgG binding to astrocyte AQP4, a blocking molecule …
Aquaporin-4 autoimmunity
A Zekeridou, VA Lennon - Neuroimmunology & Neuroinflammation, 2015 - AAN Enterprises
… molecular-based techniques, the most sensitive and specific being immunofluorescence
applied to indicator cells expressing recombinant AQP4 … a better outcome in the post–AQP4-IgG …
applied to indicator cells expressing recombinant AQP4 … a better outcome in the post–AQP4-IgG …
Can variation in aquaporin 4 gene be associated with different outcomes in traumatic brain edema?
RR Romeiro, MA Romano-Silva, L De Marco… - Neuroscience …, 2007 - Elsevier
… We did not find any molecular variation in exon 4 of the AQP4 gene in our sample. Even the
… could be established between AQP4 genetic variability and TBI presentation and outcome. …
… could be established between AQP4 genetic variability and TBI presentation and outcome. …
Physiological roles of aquaporin-4 in brain
EA Nagelhus, OP Ottersen - Physiological reviews, 2013 - journals.physiology.org
… Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly
prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While AQP4 …
prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While AQP4 …
[HTML][HTML] Targeting aquaporin-4 subcellular localization to treat central nervous system edema
… The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates
water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4 cell-…
water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4 cell-…
Aquaporin-4 polymorphisms predict amyloid burden and clinical outcome in the Alzheimer's disease spectrum
… the glymphatic system through aquaporin-4 (AQP4) water channels. Genetic variation of
AQP4 may impact water channel function, Aβ clearance, and clinical outcomes. We examined …
AQP4 may impact water channel function, Aβ clearance, and clinical outcomes. We examined …
Aquaporin 4 expression and tissue susceptibility to neuromyelitis optica
M Matiello, J Schaefer-Klein, D Sun… - JAMA …, 2013 - jamanetwork.com
… with NMO and controls is the presence of NMO-IgG autoantibody in serum and not the
molecular expression of AQP4, at least as measured with the techniques used in this study. …
molecular expression of AQP4, at least as measured with the techniques used in this study. …
The role of aquaporin 4 in the brain
C Iacovetta, E Rudloff, R Kirby - Veterinary Clinical Pathology, 2012 - Wiley Online Library
… in rats,71 and outcome is worse with up-regulation of AQP4, … As AQP4 molecules are anchored
to the cell membrane by … , dystrophin molecules play a role in localization of AQP4 to the …
to the cell membrane by … , dystrophin molecules play a role in localization of AQP4 to the …
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