… Pancreatic cancers arise predominantly from ductal epithelial cells of the exocrine pancreas
and are of the ductal adenocarcinoma histological subtype (PDAC). PDAC is an aggressive …

… for earlyscreening for pancreas cancer by molecular analysis of either … pancreatic cancer
(familial pancreatic cancer), andgreater than 600 have a family member with pancreatic cancer, …

… of the molecular biology of pancreatic cancer can now be brought … pancreatic cancer will
be fought and won. First, patients with a family history of pancreatic cancer or of other cancers …

… Pancreatic cancer remains stubbornly resistant to many key cytotoxic chemotherapeutic
agents and novel targeted therapies. The molecular heterogeneity of this cancer … of pancreatic …

… Although crucial advances in our understanding of the molecular pathogenesis of the disease
have been made, the exceptional aggressiveness of PDAC remains largely unexplained. …

… for pancreatic cancer that have been tested in clinical trials. … These data suggest that
treatments for pancreatic cancer … in therapies for pancreatic cancer that have been tested both …

The preponderance of pancreatic malignancies is constituted by pancreatic ductal
adenocarcinomas, abbreviated as either PDA or PDAC in the literature and used interchangeably …

… pancreatic ductal … pancreatic cancer refers almost always to the PDAC. In this review we
are also dealing with the PDAC (from now on will be referred as pancreatic cancer or pancreatic …

… pathogenesis of pancreatic carcinoma and to describe their functions within the biological
pathways that lead to pancreatic … of molecular tumor progression of pancreatic carcinoma, as …

… pancreatic neuroendocrine tumor. This review summarizes the molecular pathogenesis of
pancreatic cancer … factors, and promising concepts “cancer stemness” and “stromal niche” for …