… Staining for COX-2 is mild in benign tissue as compared to prostate carcinoma tissue. Expression
of COX2 … Interestingly, COX-2 expression in prostate carcinoma tissues is greater in the …

… of COX activity) for colorectal cancers (CRCs). COX-2, the inducible isoform of cyclooxygenase,
is … and pathways by which COX-2 plays an important role in carcinogenesis. Selective …

… inhibitors of COX-2 are effective in the prevention and treatment of cancer. Multiple lines
of evidence indicate that cyclooxygenase 2 (COX-2) is a bona fide pharmacological target for …

… and valdecoxib, two cyclooxygenase 2 (COX-2) specific inhibitors, on account of their
significant cardiovascular toxicity has raised concerns about this class of compounds [2]. In this …

… The recognition of PDKI as a target of celecoxib prompted subsequent structure-activity
analysis combined with molecular modeling to generate COX-2 inactive celecoxib derivatives …

… both COX-1 and COX-2, particularly the aspirin. These drugs exert their therapeutic effects by
inhibiting COX2-dependent prostanoid biosynthesis and COX-… Molecular docking analyzes …

… Currently, cyclooxygenase-2 (COX-2), an inducible enzyme that catalyzes the synthesis of
… molecular target for chemopreventive agents.3 This article provides an overview of COX-2 …

… can stimulate COX activity and that its pro-angiogenic effect is mainly mediated by COX-2-…
experimental data on the molecular mechanisms underlying iNOS-COX-2 cross-talk and …

… From these evidences, it is indicated that COX-2 becomes a potent molecular target for …
of COX-2 and iNOS expression of the target lesions. We have recently reported that COX-2 …

… able to anticipate that selective COX-2 inhibitors would enhance the effect of … COX-2 is a
promising molecular target for cancer therapy and that overcoming the adverse impact of COX-2 …