… MYC expression that involves a four-stranded DNA structure, termed a G-quadruplex, amenable
to small molecule targeting. … the NHE III 1 in the MYC promoter are the closest thing that …

… and therapeutic strategies against cancer using small molecules targeting the oncogene, …
of agents targeting c-Myc, in particular G-quadruplexes formed in c-Myc promoter and c-Myc/…

… MYC:MAX complexes, reducing MYC promoter occupancy and effectively suppressing
transcription. A recent study from Jung et al. [59] demonstrated that under physiologic levels …

… important insights into targeting the major G4 of the MYC promoter by small molecules. The
newly … It has drug-like properties with low molecular weight, which makes it a promising lead-…

… of all 3 forms of MYC to their target promoters, has been shown to … targeting MYC has yet
progressed to clinical testing, APTO-253, which partly acts by decreasing expression of MYC, is …

… To test whether the inhibition of nucleolin transactivation by Omomyc was due to a
reduction of promoter binding, we measured the amount of Myc bound to the nucleolin …

… MYC expression is complex and involves multiple promoters and transcriptional start sites.
P1 and P2 seem to be the predominant promoters … -MYC promoter controls 85–90% of c-MYC …

… The particular transcriptional system we have described, the MYC promoter, is … -molecule
targeting, which provides several distinct advantages over oligomer targeting for molecular …

… MYC overexpression (20). A few lately reported molecular binders that stabilize the c-MYC
promoter … 21–24), which supports that c-MYC could be an important drug target. The nuclease …

… characterization to target the G-quadruplex in the c-MYC promoter in an attempt to find
compounds that could down-regulate the expression of c-MYC at the transcriptional level. …