Multi‐omic integration of DNA methylation and gene expression data reveals molecular vulnerabilities in glioblastoma
P Santamarina‐Ojeda, JR Tejedor, RF Pérez… - Molecular …, 2023 - Wiley Online Library
… In this study, we have performed genome-wide transcriptomic and DNA methylation … -specific
vulnerabilities within GBM IDHWT tumours and identifying potential molecular pathways …
vulnerabilities within GBM IDHWT tumours and identifying potential molecular pathways …
Making it or breaking it: DNA methylation and genome integrity
… DNA methylation and DNA repair processes, although the molecular function of DNA
methylation in DNA … that could provide genetic vulnerabilities to these compounds can offer …
methylation in DNA … that could provide genetic vulnerabilities to these compounds can offer …
Molecular mechanisms underlying the link between diet and DNA methylation
FZ Kadayifci, S Zheng, YX Pan - International journal of molecular …, 2018 - mdpi.com
… the effects of nutrition on DNA methylation pathways, but to our … in DNA methylation and
demethylation. We also aim to go through all of the possible nutrient and DNA methylation …
demethylation. We also aim to go through all of the possible nutrient and DNA methylation …
Methyl nutrients, DNA methylation, and cardiovascular disease
… Furthermore, epigenetic regulation of gene expression and DNA methylation profiles are
tissue and cell specific so the vulnerability will be cell and tissue specific and dependent on the …
tissue and cell specific so the vulnerability will be cell and tissue specific and dependent on the …
Exploiting epigenetic vulnerabilities for cancer therapeutics
… DNA methylation also affect the cell mutation rate, for instance, through higher rates of
spontaneous deamination at methylated … Not only DNA methylation but also histone methylation, …
spontaneous deamination at methylated … Not only DNA methylation but also histone methylation, …
The impact of metabolism on DNA methylation
CL Ulrey, L Liu, LG Andrews… - Human molecular …, 2005 - academic.oup.com
… DNA methylation is critical for developmental changes in gene regulation, the classic model
being promoter methylation in … for the defect are vulnerable to hyperhomocysteinemia when …
being promoter methylation in … for the defect are vulnerable to hyperhomocysteinemia when …
Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation
MM Mitchener, TW Muir - Molecular cell, 2022 - cell.com
… fidelity down unique cell lineages is at the core of molecular epigenetics research. One key
component of this elaborate choreography is the covalent modification of DNA and histones ( …
component of this elaborate choreography is the covalent modification of DNA and histones ( …
DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker
J Tost - Molecular biotechnology, 2010 - Springer
… DNA methylation patterns are susceptible to change in response to environmental stimuli …
to be most vulnerable during early in utero development. Aberrant DNA methylation changes …
to be most vulnerable during early in utero development. Aberrant DNA methylation changes …
Minireview: epigenomic plasticity and vulnerability to EDC exposures
CL Walker - Molecular Endocrinology, 2016 - academic.oup.com
… Both DNA methylation and histone modifications have been shown to be vulnerable to
disruption … into epigenomic plasticity that is vulnerable to disruption by environmental exposures. …
disruption … into epigenomic plasticity that is vulnerable to disruption by environmental exposures. …
DNA methylation-based predictors of health: applications and statistical considerations
… to the development of DNA methylation-based predictors across a … the progress of existing
DNA methylation-based predictors, … capacity for functional molecular interpretation. However, …
DNA methylation-based predictors, … capacity for functional molecular interpretation. However, …
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