[HTML][HTML] A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG …

R Galot, C Le Tourneau, E Saada-Bouzid… - European Journal of …, 2021 - Elsevier
… combination of monalizumab and cetuximab in patients with R/… However, there are no data
of single-agent monalizumab in … study evaluating monalizumab monotherapy in R/M SCCHN. …

[HTML][HTML] Monalizumab in combination with cetuximab in patients (pts) with recurrent or metastatic (R/M) head and neck cancer (SCCHN) previously treated or not with …

RB Cohen, G Lefebvre, MR Posner, JR Bauman… - Annals of …, 2019 - Elsevier
… The multicenter phase II trial tested the combination of monalizumab and cetuximab in pts
with R/M SCCHN. Pts received monalizumab 10 mg/kg q2weeks and cetuximab according to …

[HTML][HTML] A phase II study of monalizumab in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN): results of the I1 cohort of …

R Galot, C Le Tourneau, E Saada-Bouzid, A Daste… - Annals of …, 2019 - Elsevier
Monalizumab (mona) is a human IgG4 antibody targeting the NKG2A receptor. … Monalizumab
(mona) is a human IgG4 antibody targeting the NKG2A receptor. Methods The UPSTREAM …

… of a phase II study evaluating monalizumab in combination with cetuximab in previously treated recurrent or metastatic squamous cell carcinoma of the head and neck …

J Fayette, G Lefebvre, MR Posner… - Annals of …, 2018 - annalsofoncology.org
Background: Monalizumab (Mona) is an immune checkpoint inhibitor targeting NKG2A receptors
expressed on tumor-infiltrating CD8 T and Natural Killer (NK cells). The NKG2A ligand, …

123MO Monalizumab, cetuximab and durvalumab in first-line treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): A …

DA Colevas, K Misiukiewicz, AT Pearson… - Annals of …, 2021 - annalsofoncology.org
Monalizumab is an immune checkpoint inhibitor targeting Natural Killer Group … of monalizumab
and cetuximab with the addition of durvalumab (cohort 3) in first-line treatment of patients

81P Monalizumab in combination with cetuximab post platinum and anti-PD-(L) 1 in patients with recurrent/metastatic squamous cell carcinoma of the head and neck  …

J Fayette, J Bauman, S Salas, D Colevas… - Annals of …, 2020 - annalsofoncology.org
… ) with 40 patients planned in each cohort. All patients received monalizumab intravenously
750 … Here we present updated analysis for Cohort 2 and an exploratory analysis of all patients

Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines

J Lee, B Keam, HR Park, JE Park, S Kim, M Kim… - Journal of Cancer …, 2023 - Springer
… Our results suggest that HLA-E surface expression is a tumor biomarker for monalizumab
efficacy and that the use of monalizumab in combination with other cancer therapies that …

… -controlled, multicenter, global study of monalizumab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma …

J Fayette, T Seiwert, RL Ferris, K Harrington, R Haddad… - Cancer Research, 2022 - AACR
… 2 study, monalizumab (… monalizumab + cetuximab in pts with R/M HNSCC previously treated
with CT and an ICI. Methods: Approximately 624 pts will be randomized 2:1 to monalizumab

854O INTERLINK-1: Phase III study of cetuximab (CTX)±monalizumab (M) in participants (pts) with recurrent/metastatic head and neck squamous cell carcinoma (R/M …

J Fayette, LFL Licitra, KJ Harrington… - Annals of …, 2023 - annalsofoncology.org
Background First-line (1L) treatment for R/M HNSCC includes ICI+/-CT or CT+ CTX. Treatment
after 1L failure is not clearly defined. Preliminary data suggest M (anti-NKG2A)+ CTX may …

Emerging monoclonal antibody therapy for head and neck squamous cell carcinoma

F Proulx-Rocray, D Soulières - Expert Opinion on Emerging Drugs, 2024 - Taylor & Francis
monalizumab, an ICI targeting NKG2A receptor ( Table 1 ). Results from the INTERLINK-1
trial, a double-blind, placebo-controlled phase III RCT, comparing monalizumabmonalizumab