… In this review we will place emphasis on monogenic, single-gene disorders … or monogenic
disease (also known as a single-gene disorder), which results from a pathogenic mutation of a …

… mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet 2006;
15(14): 2216-24. http://dx.doi.org/10.1093/hmg/ddl147 PMID: 16760222 [17] Mishra R, Chesi A, …

… mutations of the mother and fetus appears important for ideal glycemic control during pregnancy,
given that maternal GCK mutations … personalized medicine in treatment of monogenic …

… monogenic inherited disorder—is known, but there are at least a dozen different possible
mutations (… The locations of the mutated genes in the monogenic (mendelian) diseases are …

… [a] Monogenic (Mendelian) traits include early examples mostly of inherited disorders, and …
of monogenic drug responses is relatively simple, involving detection of underlying mutations; …

… ) caused by a mutation in a single gene … personalized medicine to patients with monogenic
diabetes faces challenges in two aspects: detecting patients suspected of having monogenic …

… of disease-causing mutations, particularly in patients with monogenic disorders. While NGS
has … and the development of personalized medicine that may arise from this new knowledge. …

… mutations, including somatic mutations, are creating opportunities to develop personalized
medicines. … In this Perspective article, we highlight the ways in which monogenic autoimmune …

… monogenic disorders have already proven useful. Such changes may usher in a new era of
personalized medicine. … of colorectal cancers where activating mutations in KRAS have been …

… Family studies revealed that the metabolism of both drugs is under monogenic control and …
23% of Asians, resulting largely from a single base pair mutation (AĺG) in exon 5 of the coding …