Morphine withdrawal‐induced morphological changes in the nucleus accumbens

S Spiga, MC Puddu, M Pisano… - European Journal of …, 2005 - Wiley Online Library
… the emergence of morphine withdrawal, viewed as a phase of opiate dependence (… morphine
withdrawal, both spontaneous and pharmacologically precipitated with the classic µ-opiate

Persistent and reversible morphine withdrawal‐induced morphological changes in the nucleus accumbens

M Diana, S Spiga, E Acquas - … of the New York Academy of …, 2006 - Wiley Online Library
… Thus, in the present article we sought to determine if morphine withdrawal-induced
spines' alteration of MSN in the subdivisions of the NAcc would persist over time and would …

Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell

R Sharf, M Sarhan, RJ DiLeone - Biological psychiatry, 2008 - Elsevier
morphine withdrawal. To understand better the neuroanatomic basis of orexin in morphine
withdrawal… responses to naloxone-precipitated morphine withdrawal in the VTA, Acb, and LC, …

Increased opioid inhibition of GABA release in nucleus accumbens during morphine withdrawal

B Chieng, JT Williams - Journal of Neuroscience, 1998 - Soc Neuroscience
… in the nucleus accumbens during withdrawal. Interneurons of the nucleus accumbens
play a key role in the integration of afferent input and regulation of the output of the nucleus (…

Nucleus accumbens D2-and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively

T Enoksson, J Bertran-Gonzalez, MJ Christie - Neuropharmacology, 2012 - Elsevier
… ► D2R and D1R-GFP transgenics can identify activated (c-Fos) nucleus accumbens
neurons. ► Both opioid withdrawal and acute morphine induce c-Fos in nucleus accumbens. ► …

Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome

GC Harris, G Aston-Jones - Nature, 1994 - nature.com
… the ability of dopamine agonists to alleviate withdrawal (n = 5, P= … nucleus accumbens, we
microinjected R-NPA (1-10 pg) into the accumbens before naloxone-precipitated withdrawal

Nucleus accumbens AMPA receptors are necessary for morphine-withdrawal-induced negative-affective states in rats

SE Russell, DJ Puttick, AM Sawyer… - Journal of …, 2016 - Soc Neuroscience
morphine dependence to show that GluA1 subunits of AMPA glutamate receptors in the
nucleus accumbens (… for aversive effects of morphine withdrawal. Using biochemical methods in …

NMDA receptor in nucleus accumbens is implicated in morphine withdrawal in rats

D Ji, ZY Sui, YY Ma, F Luo, CL Cui, JS Han - Neurochemical research, 2004 - Springer
morphine withdrawal symptoms in rats, (b) it is unlikely that this is due to the interference on
motor functions, (c) NMDA receptors in nucleus accumbens, … inhibiting morphine withdrawal

Repeated morphine exposure decreased the nucleus accumbens excitability during short‐term withdrawal

LJ Heng, J Yang, YH Liu, WT Wang, SJ Hu, GD Gao - Synapse, 2008 - Wiley Online Library
… However, the cellular neuroadaptations that take place in accumbens neurons after … how
nucleus accumbens neuronal excitability becomes affected in rats exposed to morphine using …

Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal

L Stinus, M Le Moal, GF Koob - Neuroscience, 1990 - Elsevier
nucleus accumbens were made dependent on morphine by subcutaneous implantation of
two 75-mg morphine … the region of the nucleus accumbens the most sensitive. Observational …