Elimination of climbing fiber instructive signals during motor learning

MC Ke, CC Guo, JL Raymond - Nature neuroscience, 2009 - nature.com
… The climbing fiber input to the cerebellum from the inferior olive is thought to act … motor
learning. We designed training conditions that did not elicit instructive signals in the climbing fibers

How do climbing fibers teach?

TS Otis, PJ Mathews, KH Lee, J Maiz - Frontiers in neural circuits, 2012 - frontiersin.org
… pathway and associative motor learning. (A… motor learning. The blue burst denotes CF
driven LTD of PFs, while the red bursts denote CF-driven LTP of either PF inputs (at MLI) or inputs

Climbing fibers provide graded error signals in cerebellar learning

Y Zang, E De Schutter - Frontiers in Systems Neuroscience, 2019 - frontiersin.org
climbing fiber signals, making the role of climbing fiber input … global errors based on climbing
fiber input. Previous data … In another study, magnitudes of both plasticity and motor learning

Gating of neural error signals during motor learning

RR Kimpo, JM Rinaldi, CK Kim, HL Payne… - Elife, 2014 - elifesciences.org
… Therefore, we assessed the extent to which the presence or absence of a spike in its climbing
fiber input on one trial predicted a change in a Purkinje cell’s simple spike response on the …

Cerebellar motor learning versus cerebellar motor timing: the climbing fibre story

RR Llinás - The Journal of physiology, 2011 - Wiley Online Library
… Simply stated then, one idea was that ‘climbing fibre input has to be strong to override … input
to the cerebellar nuclei. The learning hypothesis proposed that the climbing fibre had no real …

Input minimization: a model of cerebellar learning without climbing fiber error signals

TJ Anastasio - Neuroreport, 2001 - journals.lww.com
… would effectively increase the frequency of their climbing fiber input, and thereby … climbing
fiber innervation of Purkinje cells into adulthood exhibit severe deficits in motor learning

Climbing fiber signaling and cerebellar gain control

G Ohtsuki, C Piochon, C Hansel - Frontiers in cellular neuroscience, 2009 - frontiersin.org
fiber and the climbing fiber input, provides the cellular correlate of forms of motor learning. …
Even if LTD is involved in motor learning, the contribution of the climbing fiber input remains …

Climbing fibers provide essential instructive signals for associative learning

NT Silva, J Ramírez-Buriticá, DL Pritchett… - Nature …, 2024 - nature.com
learning depends on instructive signals that shape the output of neural circuits to support
learned changes in behavior. Climbing fiber (CF) inputs … shown to instruct motor adaptation of …

Climbing fibers predict movement kinematics and performance errors

ML Streng, LS Popa, TJ Ebner - Journal of …, 2017 - journals.physiology.org
… carry multiple and predictive signals for online motor control. … carried by climbing fiber
input to the cerebellar cortex. First, CS discharge modulates not only with motor performance …

The role of the cerebellum in motor control and motor learning

ME Anderson - Physical Medicine and Rehabilitation Clinics of North …, 1993 - Elsevier
… bration between the sensory input and the motor output, which we might call short-term
motor learning, or whether it is simply the adoption of a different motor strategy comes when the …