Associative and motor learning in 12-month-old transgenic APP+ PS1 mice

M Ewers, DG Morgan, MN Gordon… - Neurobiology of …, 2006 - Elsevier
… (APP + PS1) mice (n = 14) and littermate control mice (n = 17) … Mice were also tested on a
motor learning task (rotorod) and … Transgenic mice had impaired motor performance on rotorod…

mTOR signaling contributes to motor skill learning in mice

Y Bergeron, L Chagniel, G Bureau… - Frontiers in molecular …, 2014 - frontiersin.org
motor learning and control has never been examined. This study investigated, in mice, the
implication of mTOR in the learning … We first observed that the rotarod learning did not alter the …

The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock‐in mouse model of Huntington's disease

RC Trueman, SP Brooks, L Jones… - European Journal of …, 2007 - Wiley Online Library
… knock-in mouse line. The results of this study validate the serial implicit learning task as a
sensitive tool for the examination of implicit and motor learning deficits in mutant mice, and …

Neuropeptide S promotes maintenance of newly formed dendritic spines and performance improvement after motor learning in mice

C Li, XJ Wu, W Li - Peptides, 2022 - Elsevier
… V pyramidal neurons in the mouse primary motor cortex after motor learning. We found that
icv … of NPS on motor skill learning in mice subjected to an accelerated rotarod learning task. …

Age-Related Changes in Motor Ability and Motor Learning in Triple Transgenic (3× TG-AD) and Control (B6129SF1/J) Mice on the Accelerating Rotarod

JJ Oore, LM Fraser, RE Brown - Proceedings of the Nova …, 2013 - dalspace.library.dal.ca
Mouse models of Alzheimer’s disease (AD) show both cognitive and … motor ability and
motor learning of male and female triple transgenic (3×Tg-AD) and control (B6129SF1/J) mice on …

Interneuronal NMDA receptors regulate long‐term depression and motor learning in the cerebellum

M Kono, W Kakegawa, K Yoshida… - The Journal of …, 2019 - Wiley Online Library
… , we examined the visual adaptation of hOKR in each Grin1 cKO mouse line. To induce
hOKR, a checked-pattern screen was repeatedly moved in a horizontal direction (15) for 60 min …

Impaired motor learning in the vestibulo-ocular reflex in mice with multiple climbing fiber input to cerebellar Purkinje cells

RR Kimpo, JL Raymond - Journal of Neuroscience, 2007 - Soc Neuroscience
… The PKCγ −/− mice exhibited no adaptive increases or decreases in … motor learning with
previous studies of the performance of PKCγ −/− mice on other cerebellum-dependent learning

Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin

I Chévere-Torres, JM Maki, E Santini, E Klann - Neurobiology of disease, 2012 - Elsevier
… We observed that ΔRG mice have mild, but significant motor learning impairments as
measured with an accelerating rotarod paradigm (Fig. 2). In contrast to our findings with ΔRG …

Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo

M Fu, X Yu, J Lu, Y Zuo - Nature, 2012 - nature.com
… To determine if motor learning alters the spatial distribution of new spines, we examined
values of D n–s in mice trained with the reaching task. We found that the distance between a …

Delayed motor learning in a 16p11. 2 deletion mouse model of autism is rescued by locus coeruleus activation

X Yin, N Jones, J Yang, N Asraoui, ME Mathieu… - Nature …, 2021 - nature.com
… Here, we reveal that micemotor learning without showing gross motor deficits. Using in
vivo two-photon imaging in awake mice, we find that layer 2/3 excitatory neurons in the motor