Cell competition controls differentiation in mouse embryos and stem cells

M Hashimoto, H Sasaki - Current Opinion in Cell Biology, 2020 - Elsevier
… in early mouse embryos revealed that cell competition is a fundamental process underlying
embryonic development. … Early mouse development is divided into preimplantation and …

Emerging mechanisms of cell competition

NE Baker - Nature Reviews Genetics, 2020 - nature.com
… .5 and E17.5, and such competition is hypothesized to be required … cell competition in the
liver and the immune system occur post-embryonically, as does cell competition in the mouse

Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

A Lima, G Lubatti, J Burgstaller, D Hu, AP Green… - Nature …, 2021 - nature.com
… by cell competition during early mouse development. Using single-cell transcriptional
profiling of eliminated mouse epiblast cells, we identify hallmarks of cell competition and …

Distinct modes of cell competition shape mammalian tissue morphogenesis

SJ Ellis, NC Gomez, J Levorse, AF Mertz, Y Ge… - Nature, 2019 - nature.com
cell competition switch is physiologically relevant: when it is perturbed, so too is barrier
formation. Our findings show that cell competition … dynamically adjusts cell competition strategies …

Cell competition in development, homeostasis and cancer

SM van Neerven, L Vermeulen - Nature Reviews Molecular Cell …, 2023 - nature.com
… the plethora of cell competition mechanisms by first distinguishing passive and active
forms of cell competition, whereafter we discuss the different modes of active cell competition. …

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

S Bowling, A Di Gregorio, M Sancho, S Pozzi… - Nature …, 2018 - nature.com
… a key effector of cell competition in the early mouse embryo, as … of defective cells in
development to promoting the expansion … roles of cell competition during mouse development

Cell competition during growth and regeneration

R Gogna, K Shee, E Moreno - Annual review of genetics, 2015 - annualreviews.org
… Here, we discuss the existing literature regarding the current landscape of cell competition,
… of cell competition. We further discuss the clinical relevance of cell competition in the …

Cell competition and its role in the regulation of cell fitness from development to cancer

A Di Gregorio, S Bowling, TA Rodriguez - Developmental cell, 2016 - cell.com
… Subsequently, in mammals it was also found that if c-Myc is overexpressed in a mosaic
fashion during the early stages of mouse development or during the onset of embryonic stem …

Cell competition: Emerging mechanisms to eliminate neighbors

R Nagata, T Igaki - Development, growth & differentiation, 2018 - Wiley Online Library
cell polarity. Studies on the mechanisms and roles of cell competition have suggested that
cell competition can … The former type of cell competition includes Minute or Myc-induced cell

[HTML][HTML] Cell competition: A historical perspective

G Morata - Developmental Biology, 2021 - Elsevier
cell competition, with special emphasis in the history of the phenomenon within the general
frame of Developmental … This work showed that cell competition occurred between cells that …