过去一年中添加的文章,按日期排序

[HTML][HTML] Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1

A Pereira, J Diwakar, G Masserdotti, S Beşkardeş… - Nature …, 2024 - nature.com
4 天前 - … architecture and DNA methylation in mouse astrocyte-to-neuron reprogramming
mediated by … PmutNgn2 leads to higher reprogramming efficiency and enhances epigenetic …

P-159 Single-cell high-throughput methylation and transcriptomic analysis indicates variations in sensitivity to Folate-mediated one-carbon metabolism in mouse …

A Reyes Palomares, A Vincelle-Nieto… - Human …, 2024 - academic.oup.com
5 天前 - … significant progress in IVF embryo culture conditions, the sensitivity to the outer
metabolic environment during the extensive genomic transformation of embryo reprogramming

Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells

C Parikh, R Glenn, Y Shi, K Chatterjee, E Swanzey… - bioRxiv, 2024 - biorxiv.org
6 天前 - mouse stock allow 44 the identification of quantitative trait loci controlling DNA
methylation … during nPSC derivation and maintenance, we used OKSM reprogramming 132 …

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

X Zhuang, Q Wang, S Joost, A Ferrena, DT Humphreys… - bioRxiv, 2024 - biorxiv.org
8 天前 - … associated gene expression signature in AT2 cells, we suppressed DNA methylation
in young wild- 413 type C57BL/6J mice by systemic administration of GSK-3484862, a …

AMPK Deficiency Increases DNA Methylation and Aggravates Colorectal Tumorigenesis in AOM/DSS Mice

Q Sun, Q Tian, A Bravo Iniguez, X Sun, H Zhang… - Genes, 2024 - mdpi.com
11 天前 - … metabolic reprogramming. In this study, wild-type and AMPK knockout mice were
subjected … , tumor size, and hyperplasia in AOM/DSS-treated mice. The aggravated colorectal …

Keep Fingers on the CpG Islands

X Zhang, RM Blumenthal, X Cheng - Epigenomes, 2024 - mdpi.com
17 天前 - mouse embryos. Notably, the resulting DNA methylation patterns were stable in adult
mice … de novo DNA methylation at previously unmethylated CGIs using ZF fusion proteins. …

iPS cell generation-associated point mutations include many C> T substitutions via different cytosine modification mechanisms

R Araki, T Suga, Y Hoki, K Imadome… - Nature …, 2024 - nature.com
25 天前 - … and mouse iPSC lines that genomic mutations are de novo events and that, in addition
to unmodified cytosine base prone to deamination, the DNA methylationreprogramming, …

Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso

H Matsuzaki, M Kimura, M Morihashi… - Epigenetics & Chromatin, 2024 - Springer
31 天前 - … and protects it from genome-wide reprogramming after fertilization. We also identified
a … somatic cells of wild-type mice, we found DNA methylation level of the endogenous H19 …

Maternal loss-of-function of Nlrp2 results in failure of epigenetic reprogramming in mouse oocytes

Z Anvar, MD Jochum, I Chakchouk, M Sharif… - 2024 - researchsquare.com
32 天前 - … transcription and DNA methylation in developing oocytes, we observed no
correlation between gene expression differences and gene-body DNA methylation differences in …

Preventing CpG island hypermethylation in oocytes safeguards mouse development

YK Kawamura, EA Ozonov, P Papasaikas, T Kondo… - bioRxiv, 2024 - biorxiv.org
36 天前 - … We refer to Ctrl mice as genetically modified mice that we … We refer to wt mice as
genetically non-modified mice that we … of intragenic DNA methylation in mouse gametic DNA