Complex History and Differentiation Patterns of the t-Haplotype, a Mouse Meiotic Driver

RK Kelemen, B Vicoso - Genetics, 2018 - academic.oup.com
… The t-haplotype, a mouse meiotic driver found on chromosome 17, has been a model for …
A recently published set of population genomics resources for wild mice includes several …

[PDF][PDF] Fertility costs of meiotic drivers

SE Zanders, RL Unckless - Current Biology, 2019 - cell.com
… Strongly deleterious alleles have been found linked to meiotic drivers. The large and
intensely-studied mouse t haplotype region is rich with examples. Sixteen different …

Effects of a male meiotic driver on male and female transcriptomes in the house mouse

A Lindholm, A Sutter, S Künzel… - Proceedings of the …, 2019 - royalsocietypublishing.org
… Here, we investigate effects of the t haplotype, an autosomal male meiotic driver in house
mice… widespread transcriptional effects of this male meiotic driver in the house mouse genome. …

Meiotic drive in house mice: mechanisms, consequences, and insights for human biology

UP Arora, BL Dumont - Chromosome Research, 2022 - Springer
… Thus, this strategy is useful as a screening tool for finding candidate meiotic driver elements,
but subsequent follow-up work is necessary to establish the biological basis of observed …

Mechanisms of meiotic drive in symmetric and asymmetric meiosis

AN Kruger, JL Mueller - Cellular and Molecular Life Sciences, 2021 - Springer
… , with a meiotic driver and a substrate the meiotic driver utilizes to bias … A universal requirement
for meiotic drivers is a DNA … For example, in mouse oogenesis, meiotic spindle poles are …

[PDF][PDF] Mechanistic insight into crossing over during mouse meiosis

SE Peterson, S Keeney, M Jasin - Molecular cell, 2020 - cell.com
… Here, we probed mechanisms of meiotic recombination in mouse spermatocytes by defining
… of meiotic recombination products in Msh2–/– F1 hybrid mice. We recovered hundreds of …

Meiotic drive of noncentromeric loci in mammalian meiosis II eggs

DMZA Silva, T Akera - Current Opinion in Genetics & Development, 2023 - Elsevier
… of the molecular mechanisms underlying female meiotic drive systems in mice. We will briefly
… focus on how noncentromeric meiotic drivers can cheat in female meiosis, using the mouse

Homeostatic control of recombination is implemented progressively in mouse meiosis

F Cole, L Kauppi, J Lange, I Roig, R Wang… - Nature cell …, 2012 - nature.com
… Spo11 het and Spo11 wt+tg mice are fertile and show no obvious meiotic defects, including
no difference in the fraction of cells at various stages of meiotic prophase (data not shown). (a…

Unravelling the mystery of female meiotic drive: where we are

FE Clark, T Akera - Open Biology, 2021 - royalsocietypublishing.org
… associated driver, or the D allele, is thought to drive in meiosis … between centromere drive
in mice and plants will provide a … , these non-centromeric meiotic drivers may be exploiting a …

[PDF][PDF] MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells

K Ishiguro, K Matsuura, N Tani, N Takeda, S Usuki… - Developmental cell, 2020 - cell.com
… for driving meiotic gene activation. Furthermore, temporally restricted expression of MEIOSIN
leads to meiotic … Overall, meiotic block observed in Meiosin KO mice was similar to those …