Chemical synthesis of the mouse mitochondrial genome
DG Gibson, HO Smith, CA Hutchison III, JC Venter… - Nature …, 2010 - nature.com
… entire 16.3-kilobase mouse mitochondrial genome from 600 … the entire 16,299-bp mouse
mitochondrial genome from 600 … the Mus musculus mitochondrial genome (GenBank accession …
mitochondrial genome from 600 … the Mus musculus mitochondrial genome (GenBank accession …
Sequence and gene organization of mouse mitochondrial DNA
MJ Bibb, RA Van Etten, CT Wright, MW Walberg… - Cell, 1981 - cell.com
… The mouse L cell mitochondrial genome has been especially well characterized … Computer
translation of both strands of the mouse mitochondrial genome in all possible phases has …
translation of both strands of the mouse mitochondrial genome in all possible phases has …
… of the mouse mitochondrial genome is not mediated by a loss or gross alteration of the paternal mitochondrial DNA or by methylation of the oocyte mitochondrial DNA
NB Hecht, H Liem, KC Kleene, RJ Distel, S Ho - Developmental Biology, 1984 - Elsevier
… in DNA sequence or methylation state of mitochondrial DNA from four differeldt testicular
cell types, we have found that the total number of mitochondrial genomes per haploid genome …
cell types, we have found that the total number of mitochondrial genomes per haploid genome …
DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome
J Guo, X Chen, Z Liu, H Sun, Y Zhou, Y Dai… - … Therapy-Nucleic Acids, 2022 - cell.com
… To assess the off-target activity of DdCBE in the mouse mitochondrial genome, we analyzed
the deep sequencing data to find DdCBE-induced single-nucleotide variants (SNVs) around …
the deep sequencing data to find DdCBE-induced single-nucleotide variants (SNVs) around …
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Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences
AN Malik, A Czajka, P Cunningham - Mitochondrion, 2016 - Elsevier
… In addition, we found that between positions 200–3000 of the mouse mitochondrial genome,
the frequency and length of NumtS were smaller and presence of other unique regions …
the frequency and length of NumtS were smaller and presence of other unique regions …
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome
P Silva-Pinheiro, CD Mutti, L Van Haute… - Nature Biomedical …, 2023 - nature.com
… in mitochondrial … gene in the mouse mitochondrial genome. We used the library, which we
named MitoKO, to produce near-homoplasmic knockout cells in vitro and to generate a mouse …
named MitoKO, to produce near-homoplasmic knockout cells in vitro and to generate a mouse …
Organization and expression of the mammalian mitochondrial genome
O Rackham, A Filipovska - Nature Reviews Genetics, 2022 - nature.com
… of mitochondrial gene expression and the most recent advances in understanding how its
regulation is fine-tuned. Changes in mitochondrial gene … Here, we focus on transgenic mouse …
regulation is fine-tuned. Changes in mitochondrial gene … Here, we focus on transgenic mouse …
Amounts of mitochondrial DNA and abundance of some mitochondrial gene transcripts in early mouse embryos
L Pikó, KD Taylor - Developmental biology, 1987 - Elsevier
… Experiments with inhibitors of mitochondrial RNA and … the mitochondrial genome is transcribed
in early mouse embryos, at least from the eight-cell stage onward and that mitochondrial …
in early mouse embryos, at least from the eight-cell stage onward and that mitochondrial …
The potential of mitochondrial genome engineering
P Silva-Pinheiro, M Minczuk - Nature Reviews Genetics, 2022 - nature.com
… , supported by deep-sequencing data in aged human individuals and in mice with increased
mitochondrial oxidative stress, have weakened the support for oxidative damage as a major …
mitochondrial oxidative stress, have weakened the support for oxidative damage as a major …
Mitochondrial genome maintenance in health and disease
WC Copeland, MJ Longley - DNA repair, 2014 - Elsevier
… effects of eliminating mitochondrial proofreading function on disease, several groups have
employed mouse models with disrupted pol γ exonuclease activity. In the first mouse model, a …
employed mouse models with disrupted pol γ exonuclease activity. In the first mouse model, a …