… have enhanced our appreciation of the etiologic complexity of type 1 diabetes in humans
and provided an example of how promising results obtained in an animal model can be …

… (CC motif) receptor (CCR) 6 production on immune cells, leading to minimal pancreatic
islet infiltration and suppression of diabetes in the NOD mouse model of type 1 diabetes. …

… We previously found in two animal models of type 1 diabetes (T1D) an increased number of
… These animal models include firstly the nonobese diabetic (NOD) mouse, which develops …

… pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models
of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. …

… regions causing type one diabetes (T1D), highlighting the need for functional models to …
Progress in localizing genes in congenic strains of the nonobese diabetic (NOD) mouse has …

… diabetes has been gaining increasing interest. In a model of type 1 diabetes, the nonobese
diabetic (NOD) mouse, we found that insulin resistance driven by lipid- and glucose-…

… biology of T1D between mice and men, … animal models of disease. Furthermore, we believe
that this re-evaluation will allow crucial, additional lessons to be learned from animal models …

… was involved in diabetes animal model development and who contributed to the release of
NOD … DIABETES Mouse and rat animal models of autoimmune diabetes have enormously …

… studies in animal models of Type 1 diabetes as an example … We would indeed maintain that
the Type 1 diabetes research … of shortcomings associated with animal models of the disease. …

… If CRP is indeed causal, then what is the mechanism of its action in diabetic renal … study,
using a mouse model of type 1 DKD induced in human CRP transgenic (Tg) mice and in vitro …