… We describe mouse models of prostate carcinoma in this … Although bone metastases
were not observed, the study … of transplantable prostate carcinoma in a large animal model. …

… metastases as they occur in men. This review discusses the animal models that have
been developed to investigate prostate cancer bone metastasis, with a focus on canine …

… of prostate cancer cells to the bone, and (3) current animal models utilized in studying prostate
cancer bone metastasis. … mouse models of prostate cancer, the TRAMP mouse model, …

… in this pursuit are animal models that recapitulate the bone metastatic progression we observe
… for bone metastatic PCa, the ideal animal models of bone metastatic PCa remain elusive. …

… Animal models of cancer … prostate cancer in mice [3] and a lack of animal model systems
that closely recapitulate the human PCa hampers the mechanistic understanding of metastatic …

… Notably, in 1991, Wang and Stearns 40 demonstrated a novel approach to developing a
mouse model of prostate cancer bone metastasis, which was relevant to the development of …

… foci, subcultured the cells and re-injected them back into the mouse model. However, no …
no longitudinal assessment animal studies of prostate cancer bone metastases using these …

… to develop a metastasis assay of human prostate cancer (PCa) growth in severe combined
immunodeficient mice. … or in the prostate (orthotopically) of severe combined immunodeficient …

… mouse models used to study prostate cancer. We also comment on how closely each model
recapitulates human prostate cancer. … difficult to induce bone metastases in mice, which is a …

… Bone metastases only occurred in 3/21 or 14% of mice [Masumori et al., 2001]. Thus, … ,
bone metastases are rare in the transgenic mouse model. All other transgenic mouse models …