… Therefore, we designed the MRC Myeloma IX trial, an innovative study with two … first-line
and maintenance treatments for adult patients with newly diagnosed multiple myeloma. The …

… optimal treatments for individual patients. The Medical Research Council (MRC) Myeloma IX
… The current analysis reports data from MRC Myeloma IX following an extended follow-up of …

… The MRC's Myeloma VII trial currently underway is also addressing this issue. Trials of
purged autologous marrow, either through positive or negative selection, have shown no …

… Results from the MRC Myeloma IX maintenance study indicate that thalidomide maintenance
has a non significant effect in improving PFS in non-intensively treated patients (Morgan et …

… First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma
(MRC Myeloma IX): … in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. …

… , the initial low availability of novel salvage therapy options … therapy, 41% of these patients
received thalidomide at first … had been uniformly treated with effective salvage therapy after …

… The treatment armamentarium has been greatly increased in … being incorporated in first-line
treatment regimens, which … , we predict that in the current treatment landscape the role of …

… ) series of randomised controlled trials of treatment in previously untreated patients with
MM up to MRC Myeloma IX provided only limited data on performance status. Myeloma IX …

… trial of treatment intensification, and the seventh Medical Research Council trial in myeloma
is … The standard treatment for newly diagnosed myeloma of stages H and II has previously …

… MRC Myeloma IX and XI trials. Smaller sub-clones may carry prognostic relevance, but data
are currently limited. UK MRC Myeloma … The oral PI ixazomib has limited data in the first line …