… in targeting mTOR for cancer therapy; a search in PubMed for ‘mTOR inhibitors cancer therapy
+ review’ … industry—in targeting mTOR signaling as a potential therapeutic avenue for anti-…

… intervention and has driven the development of a number of mTOR inhibitors. Encouraging
… setting, mTOR inhibitors remain a promising therapeutic option for the treatment of cancer. …

… Dual PI3K/mTOR kinase inhibitors have been developed with the idea of overcoming
resistance to the mTOR inhibition through preventing the activation of PI3K/Akt as a result of …

… of mTOR inhibitor resistance and outlines strategies to improve mTOR inhibitor-based
therapy. … mTOR inhibitors have recently demonstrated therapeutic activity against mantle cell …

… , and non-small-cell lung cancer. The results of ongoing clinical trials with mTOR inhibitors,
as single agents and in combination regimens, will better define their activity in cancer. …

… To the best of our knowledge, the following mTOR inhibitors are actually believed to represent
potentially useful agents for cancer therapy (See Table 2). For several of them there are …

… in exploring mTOR signaling and the development of mTOR inhibitors for cancer therapy. In
… , we discuss the mechanisms underlying the resistance to mTOR inhibitors in cancer cells. …

… inhibiting mTOR directly, given that mTOR inhibition in most instances is cytostatic rather
than cytotoxic? As described above there are in vitro and in vivo models where mTOR inhibitors …

… other ATP-competitive mTOR inhibitors or PI3K/mTOR dual inhibitors have been … mTOR
inhibition assays, and representative compound 1 was reported to be a potent mTOR inhibitor …

… of inhibiting mTOR signaling, either in the mTORC1 or mTORC2 … : mTOR signaling and cancer
therapy (chapters “mTORC1: A … of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor …