… of mTOR and stimulate the activation of the mTOR … of mTOR signaling by a variety of stimuli
[85,86,87]. The elevated expression of either PLD1 or PLD2 activates mTORC1 signaling in …

… Moreover, we discuss the relationship between mTORC1 and … by mTORC1 and its impact
on cancer are discussed. Finally, we also review the therapeutic efficacy of mTORC1 inhibitors …

… Thus, further understanding of the roles of mTOR signaling in IL-17 expression is important.
… of mTORC1 signaling that govern IL-17 expression. This review mainly focuses on mTORC1, …

… of PI3K/Akt/mTOR signaling in cancer and summarizing efforts for developing PI3K/Akt/mTOR
inhibitors as either mono-therapy or combination therapy in different cancer settings. We …

… mTORC1 to lysosomes to activate mTORC1 (8). mLST8 binds to the kinase domain of mTOR
and strongly enhances mTOR signaling… Rictor-mTOR, but not the Raptor-mTOR, interaction …

… receptors or alterations and mutations of PI3K signaling. Rapamycin and its analogues (…
mTORC1 signaling via an allosteric mechanism. Research has shown that inhibition of mTOR is …

… mTORC1 signaling also has important functions in the innate (49) and adaptive immune
system (50–52). Specifically a role for mTORC1 … Deregulated mTORC1 signaling was found in …

… attractive therapeutic target in ovarian cancer. Currently, several inhibitors of PI3K pathway,
such as PI3K/AKT inhibitors, rapamycin analogs for mTOR inhibition, and dual PI3K/mTOR …

… PI3K signaling for proliferation and survival, endothelial cell proliferation may also be
dependent on mTOR signaling. Tumor angiogenesis may depend on mTOR signaling through …

… development of mTOR-pathway … to therapeutic targeting of mTOR-associated mTORC1
and mTORC2 in breast cancer. We have also comprehensively summarized regulation of mTOR …