[HTML][HTML] The mu-opioid receptor is a molecular marker for poor prognosis in hepatocellular carcinoma and represents a potential therapeutic target

DT Chen, JH Pan, YH Chen, W Xing, Y Yan… - British journal of …, 2019 - Elsevier
… features and a worse prognosis. Depletion of MOP suppressed cell … HCC metastasis and
poor prognosis. Morphine promotes cell … Its overexpression is associated with poor prognosis in …

[HTML][HTML] Association of mu-opioid receptor (MOR) expression and opioids requirement with survival in patients with stage I-III pancreatic ductal adenocarcinoma

H Zhang, M Qu, A Gorur, Z Sun, JP Cata… - Frontiers in …, 2021 - frontiersin.org
… with high opioid consumption was associated with poor prognosis in … poor survival in stage
I-III PDAC but associated with perineural invasion. Patients requiring high amounts of opioids

[HTML][HTML] Increased mu-opioid receptor expression is associated with reduced disease-free and overall survival in laryngeal squamous cell carcinoma

H Zhang, M Sun, D Zhou, A Gorur, Z Sun… - British journal of …, 2020 - Elsevier
… with poor prognosisprognosis in oesophageal squamous cell carcinoma or colorectal
cancers. Two retrospective studies have indicated that opioids are associated with poor prognosis

[HTML][HTML] Mu opioid receptor mRNA overexpression predicts poor prognosis among 18 common solid cancers: A pan-cancer analysis

W Sun, S Zhuang, M Cheng, Z Qiu - Frontiers in Oncology, 2023 - frontiersin.org
… Background: Opioids are widely used for patients with solid … to investigate the prognostic
features of Mu opioid receptor (… Our pan-cancer analysis only focused on Mu Opioid Receptor …

Opioids and cancer prognosis: A summary of the clinical evidence

MF Ramirez, A Gorur, JP Cata - Neuroscience Letters, 2021 - Elsevier
… The mu opioid receptor could be used as an actionable target for the treatment of … Current
evidence suggests that pain is associated with poor clinical outcomes in patients with cancer. …

[HTML][HTML] Mu opioid receptor 1 (MOR-1) expression in colorectal cancer and oncological long-term outcomes: a five-year retrospective longitudinal cohort study

O Díaz-Cambronero, G Mazzinari, F Giner, A Belltall… - Cancers, 2020 - mdpi.com
… recurrences, associated with poor long-term prognosis [2]. … Type 1 mu opioid receptor (MOR-1)
agonist drugs such as … In addition, analgesics such as opioids may promote cancer …

[HTML][HTML] Association of mu-opioid receptor expression with long-term survival and perineural nerve invasion in patients undergoing surgery for ovarian cancer

H Zhang, M Qu, C Sun, Y Wang, T Li, W Xu… - Frontiers in …, 2022 - frontiersin.org
… long-term prognosis of ovarian cancer … poor prognosis in ovarian cancer. In addition, we
determined the impact of MOR expression on length of hospital stay (LOS), intraoperative opioid

[HTML][HTML] Pain, opioid therapy, and survival: a needed discussion

DM Novy, DV Nelson, D Koyyalagunta, JP Cata… - Pain, 2020 - journals.lww.com
… activity of opioids is mediated through mu-opioid receptors (… the known adverse prognostic
effect of pain in malignancies. … MOR expression is associated with poorer clinical outcomes in …

Targeting the mu-opioid receptor for cancer treatment

H Zhang, D Zhou, J Gu, M Qu, K Guo, W Chen… - Current Oncology …, 2021 - Springer
… of opioids on the prognosis of cancer patients. Previous studies found that the expression
level of MOR was associated with tumor grade and prognosis. … opioids had significantly poorer

Individualized use of methadone and opioid rotation in the comprehensive management of cancer pain associated with poor prognostic indicators

D Fan, E Bruera - Pain, 1996 - Elsevier
… free of opioid toxicity. Our findings illustrate a role of methadone in the management of cancer
pain associated with poor prognostic … rotation to another opioid. Possible mechanism for …