… Since opioid ligands also possess an amine, a homologous … receptor was mutated to Asn,
several opioid receptor ligands … of pharmacophores for opioid receptor ligands has flourished. …

… has allowed for the development of biased ligands with robust clinical efficacy and fewer …
mu opioid receptor pharmacology and highlight how far opioid pharmacology has evolved. …

… At the same time the search for naturally occurring µ receptor ligands was going on. A …
like opioid receptor ligands able to address opioidergic systems. The bioactivities of opioid …

… Given the high homology between the murine and human mu opioid receptors, we … of
the human receptor, especially in regard to ligand binding and in vitro G protein activation. …

… Binding model of biased ligands and the classical opiates at mu-opioid receptors (μ-ORs).
(a… ) and biased ligands (orange). (b) Detail of binding model for biased ligands represented by …

… and receptor reserve. These are important concepts in light of the increasing efforts to identify
biased ligands for opioid receptors … is essential for the detection of ligand bias. Taking the …

… We hypothesized that small molecule NOP receptor ligands that have mixed NOP/μ-opioid
activity may have an attractive profile with respect to pain and addiction ( Khroyan et al., 2007 …

… opioid receptor ligand. It bears little structural similarity to other structural classes of nonpeptidic
opioid receptor ligands, … charged nitrogen atom in opioid compounds represented an …

… of food-derived opioid peptides as exogenous opioid receptor ligands in relation to the …
nutraceutical significance of food protein-derived opioid receptor ligands will be discussed. …

… has been shown to behave like opioid receptor ligands able to address opioidergic systems
… properties; the other peptides behave like opioid receptor agonists. Most of the information …