… Our findings identify impaired mucus detachment from CF submucosal glands as a primary
defect that disrupts MCT. Na + hyperabsorption by airway surface epithelia and periciliary …

… Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis…
Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from …

… Airway mucus obstruction is a key feature of cystic fibrosis (CF) and chronic obstructive
pulmonary … Airway mucus obstruction is a key feature of cystic fibrosis and chronic obstructive …

… , and since bicarbonate has the ability to bind calcium, we hypothesized that the calcium
chelating property of OligoG would lead to detachment of CF mucus. Indeed, OligoG could …

… We conclude that treatment of CF small intestinal mucus with HS causes detachment of
mucus from the epithelium by a process unrelated to bicarbonate. Bacteria are trapped in the …

… of altered mucus that is even more difficult to clear. Thus, high amounts of stagnate mucus
accumulate in later stages of cystic fibrosis (CF) and chronic obstructive pulmonary disease (…

… Airway mucus obstruction is common to many chronic lung diseases such as asthma, chronic
obstructive pulmonary disease (COPD) as well as cystic fibrosis (… /detachment of the mucus …

… 2A), we analyzed the mucus detaching properties of new generation ENaC inhibitors in
mouse ileum. Compound A was previously evaluated for its ability to inhibit ENaC (Åstrand et al., …

… importance of mucus in the intestine and lungs in relation to the diseases cystic fibrosis (CF)…
will generate an attached mucus layer and that its activation help to detach the mucus. The …

… these substances to detach F508del-CFTR mutant mouse ileal mucus. … detach the mucus
to the level of WT mucus. (D) Ab-PAS stained sections revealed expanded and blistery mucus …