… Studies of the genetic disease cystic fibrosis (CF) have been central to much of our current
understanding of the function of the mucus barrier in health and its dysfunction in disease, …

… Airway mucus obstruction is a key feature of cystic fibrosis (CF) and chronic obstructive
pulmonary disease (COPD… Airway mucus obstruction is a key feature of cystic fibrosis and chronic …

… Since the first description of cystic fibrosis (CF) more than 50 years ago, it has been known
… airway mucus was based, in part, on recognition of the severe bowel obstruction due to …

… In muco‐obstructive diseases like CF, restoring proper mucus viscoelasticity and clearance
in the lungs remain major goals. The advancement of CFTR correctors and modulators …

… lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic
… ‐like lung disease support the concept that mucus plugging per se can trigger inflammation …

… ) in cystic fibrosis (CF) airway epithelial cells are associated with airway mucus hypersecretion…
, to severe airway obstruction with hyperviscous and adhesive airway mucus. Whether the …

… not mucus obstruction and … mucus obstruction in the absence of mucus hypersecretion
indicating that additional rehydration therapies may be necessary for effective treatment of mucus …

… Cystic fibrosis (CF) was first recognized as a separate … disease of mucus plugging of the
glandular ducts, termed “cystic … CF usually consists of obstructive biliary cirrhosis, characterized …

… Beyond obstruction of airflow, excessive mucus that fails to clear may form plaques and
plugs that can serve as a nidus for infection by opportunistic pathogens, especially facultative …

… Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis … dysfunction causes chronic mucus obstruction, neutrophilic inflammation …