Dabrafenib in patients with BRAFV600E-positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial

D Planchard, TM Kim, J Mazieres, E Quoix… - The Lancet …, 2016 - thelancet.com
… In this phase 2, multicentre, non-randomised, open-label study, we enrolled previously
treated and untreated patients with stage IV metastatic BRAF V600E -positive NSCLC. Patients …

… first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 …

R Rosell, E Carcereny, R Gervais… - The lancet …, 2012 - thelancet.com
… In our open-label, multicentre, randomised phase 3 trial we enrolled eligible participants
attending hospitals in France, Italy, and Spain. Eligibility criteria included histological diagnosis …

Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial

SJ Antonia, JA López-Martin, J Bendell, PA Ott… - The Lancet …, 2016 - thelancet.com
Background Treatments for small-cell lung cancer (SCLC) after failure of platinum-based
chemotherapy are limited. We assessed safety and activity of nivolumab and nivolumab plus …

Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study

G Goss, CM Tsai, FA Shepherd, L Bazhenova… - The lancet …, 2016 - thelancet.com
… We assessed the efficacy and safety of osimertinib in patients with EGFR Thr790Met-positive
non-small-cell lung cancer (NSCLC), who had progressed after previous therapy with an …

Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled …

L Fehrenbacher, A Spira, M Ballinger, M Kowanetz… - The Lancet, 2016 - thelancet.com
Background Outcomes are poor for patients with previously treated, advanced or metastatic
non-small-cell lung cancer (NSCLC). The anti-programmed death ligand 1 (PD-L1) antibody …

Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3 …

A Sezer, S Kilickap, M Gümüş, I Bondarenko… - The Lancet, 2021 - thelancet.com
Background We aimed to examine cemiplimab, a programmed cell death 1 inhibitor, in the
first-line treatment of advanced non-small-cell lung cancer with programmed cell death ligand …

… target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised, controlled trial

U Nestle, T Schimek-Jasch, S Kremp… - The Lancet …, 2020 - thelancet.com
Multi-centre calibration of an adaptive thresholding method for PET-based delineation of
tumour volumes in radiotherapy planning of lung cancer. … radiotherapy planning of lung cancer. …

Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1–2 trial

AT Shaw, BJ Solomon, R Chiari, GJ Riely… - The Lancet …, 2019 - thelancet.com
… In this multicentre, open-label, single-arm, phase 1–2 study, we examined the antitumour …
Open-Label, multicenter, phase ii study of ceritinib in patients with non-small-cell lung cancer

Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial

DW Kim, R Mehra, DSW Tan, E Felip… - The lancet …, 2016 - thelancet.com
Background ALK-rearranged non-small-cell lung cancer (NSCLC) is sensitive to ALK tyrosine
kinase inhibitors (ALK inhibitors) such as crizotinib, but resistance invariably develops, …

Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial

AT Shaw, E Felip, TM Bauer, B Besse… - The Lancet …, 2017 - thelancet.com
lung cancer using the terms “ALK”, “ROS1”, “lung cancer”, … Association for the Study of
Lung Cancer meeting) using the … non-small-cell lung cancers (NSCLCs) are responsive to the …