A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms
… Multiple testing is a challenging issue in genetic association studies using large numbers of
single nucleotide polymorphism (SNP… Failure to adjust for multiple testing appropriately may …
single nucleotide polymorphism (SNP… Failure to adjust for multiple testing appropriately may …
A comprehensive review of genetic association studies
JN Hirschhorn, K Lohmueller, E Byrne… - Genetics in …, 2002 - nature.com
… effects, large studies and/or meta-analyses of multiple studies will often be required to
determine whether genetic associations between polymorphisms and disease are significant. …
determine whether genetic associations between polymorphisms and disease are significant. …
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin
AJ Saunders, L Bertram, K Mullin… - … molecular genetics, 2003 - academic.oup.com
… Based on the biological and genetic data … polymorphisms in A2M for genetic association
with AD (Table 1). Family-based association studies have been largely supportive of genetic …
with AD (Table 1). Family-based association studies have been largely supportive of genetic …
Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis
R Goertsches, M Comabella, A Navarro… - Journal of …, 2005 - Elsevier
… gene for susceptibility to multiple sclerosis (MS). Eight single nucleotide … gene-based
haplotypes in the population by computational procedures and demonstrated genetic association …
haplotypes in the population by computational procedures and demonstrated genetic association …
Genetic association of HLA‐DRB1 multiple polymorphisms with dermatomyositis in Chinese population
JM Lin, YB Zhang, QL Peng, HB Yang, JL Shi, ML Gu… - Hla, 2017 - Wiley Online Library
Genetic association of HLAâ•’DRB1 multiple polymorphisms with dermatomyositis in … A
multi-national Arab genome-wide association study identifies new genetic associations for rheu…
multi-national Arab genome-wide association study identifies new genetic associations for rheu…
Comprehensive review of genetic association studies and meta-analyses on miRNA polymorphisms and cancer risk
K Srivastava, A Srivastava - PloS one, 2012 - journals.plos.org
… , progression and prognosis of multiple human malignancies. The present study was
aimed to investigate the association between four highly studied miRNA polymorphisms (mir-146a …
aimed to investigate the association between four highly studied miRNA polymorphisms (mir-146a …
Genetic association studies of complex traits: design and analysis issues
C Newton-Cheh, JN Hirschhorn - Mutation Research/Fundamental and …, 2005 - Elsevier
… were discovered (usually restriction fragment length polymorphisms (RFLPs)), a number
of … SNPs for a genetic association study. SNPs can be chosen to tag other SNPs or multi-SNP …
of … SNPs for a genetic association study. SNPs can be chosen to tag other SNPs or multi-SNP …
Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles
M Niino, T Fukazawa, I Yabe, S Kikuchi… - Journal of the …, 2000 - Elsevier
… association between Bsm I polymorphism, one of the vitamin D receptor genes (VDRG)
polymorphism, and multiple … Apa I polymorphism was detected by PCR-RFLP from the DNA of 77 …
polymorphism, and multiple … Apa I polymorphism was detected by PCR-RFLP from the DNA of 77 …
What makes a good genetic association study?
AT Hattersley, MI McCarthy - the Lancet, 2005 - thelancet.com
… Genetic association studies are central to efforts to identify and characterise genomic variants
underlying susceptibility to multifactorial disease. However, obtaining robust replication of …
underlying susceptibility to multifactorial disease. However, obtaining robust replication of …
Genetic association studies
HJ Cordell, DG Clayton - The Lancet, 2005 - thelancet.com
… association between a genetic polymorphism and a trait might exist in a given population: (1)
the polymorphism has a causal role; (2) the polymorphism … ; or (3) the association is due to …
the polymorphism has a causal role; (2) the polymorphism … ; or (3) the association is due to …
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