A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms

X Gao, J Starmer, ER Martin - … of the International Genetic …, 2008 - Wiley Online Library
Multiple testing is a challenging issue in genetic association studies using large numbers of
single nucleotide polymorphism (SNP… Failure to adjust for multiple testing appropriately may …

A comprehensive review of genetic association studies

JN Hirschhorn, K Lohmueller, E Byrne… - Genetics in …, 2002 - nature.com
… effects, large studies and/or meta-analyses of multiple studies will often be required to
determine whether genetic associations between polymorphisms and disease are significant. …

Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin

AJ Saunders, L Bertram, K Mullin… - … molecular genetics, 2003 - academic.oup.com
… Based on the biological and genetic data … polymorphisms in A2M for genetic association
with AD (Table 1). Family-based association studies have been largely supportive of genetic

Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis

R Goertsches, M Comabella, A Navarro… - Journal of …, 2005 - Elsevier
gene for susceptibility to multiple sclerosis (MS). Eight single nucleotide … gene-based
haplotypes in the population by computational procedures and demonstrated genetic association

Genetic association of HLA‐DRB1 multiple polymorphisms with dermatomyositis in Chinese population

JM Lin, YB Zhang, QL Peng, HB Yang, JL Shi, ML Gu… - Hla, 2017 - Wiley Online Library
Genetic association of HLAâ•’DRB1 multiple polymorphisms with dermatomyositis in … A
multi-national Arab genome-wide association study identifies new genetic associations for rheu…

Comprehensive review of genetic association studies and meta-analyses on miRNA polymorphisms and cancer risk

K Srivastava, A Srivastava - PloS one, 2012 - journals.plos.org
… , progression and prognosis of multiple human malignancies. The present study was
aimed to investigate the association between four highly studied miRNA polymorphisms (mir-146a …

Genetic association studies of complex traits: design and analysis issues

C Newton-Cheh, JN Hirschhorn - Mutation Research/Fundamental and …, 2005 - Elsevier
… were discovered (usually restriction fragment length polymorphisms (RFLPs)), a number
of … SNPs for a genetic association study. SNPs can be chosen to tag other SNPs or multi-SNP …

Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles

M Niino, T Fukazawa, I Yabe, S Kikuchi… - Journal of the …, 2000 - Elsevier
association between Bsm I polymorphism, one of the vitamin D receptor genes (VDRG)
polymorphism, and multiple … Apa I polymorphism was detected by PCR-RFLP from the DNA of 77 …

What makes a good genetic association study?

AT Hattersley, MI McCarthy - the Lancet, 2005 - thelancet.com
Genetic association studies are central to efforts to identify and characterise genomic variants
underlying susceptibility to multifactorial disease. However, obtaining robust replication of …

Genetic association studies

HJ Cordell, DG Clayton - The Lancet, 2005 - thelancet.com
association between a genetic polymorphism and a trait might exist in a given population: (1)
the polymorphism has a causal role; (2) the polymorphism … ; or (3) the association is due to …