Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - … and targeted therapy, 2021 - nature.com
… are the two main courses driving the pathogenesis of COVID-19. Both the virus … potential
targets for antiviral therapy. Hence, in this study, the current therapeutic strategies of COVID-19 …
targets for antiviral therapy. Hence, in this study, the current therapeutic strategies of COVID-19 …
COVID-19: drug targets and potential treatments
C Gil, T Ginex, I Maestro, V Nozal… - Journal of medicinal …, 2020 - ACS Publications
… Through the journey across the life cycle of the virus presented in this Perspective, we have
considered several virus-based and host-based targets as objectives for pharmacological …
considered several virus-based and host-based targets as objectives for pharmacological …
Approaches to the potential therapy of COVID-19: a general overview from the medicinal chemistry perspective
JC Menéndez - Molecules, 2022 - mdpi.com
… as a potential target for COVID-19 therapy. Inhibitors of this … , COVID-19 therapy is conditioned
by the existence of two … The main viral targets for potential drugs are the viral S protein…
by the existence of two … The main viral targets for potential drugs are the viral S protein…
Precision therapeutic targets for COVID-19
ZA Krumm, GM Lloyd, CP Francis, LH Nasif… - Virology journal, 2021 - Springer
… These steps offer several opportunities for therapeutic targeting. The receptor … therapeutic
option as it offers the potential for long-term immunity. The S protein is the logical target for …
option as it offers the potential for long-term immunity. The S protein is the logical target for …
Therapeutic targets and potential agents for the treatment of COVID‐19
Y Wu, Z Li, YS Zhao, YY Huang… - Medicinal Research …, 2021 - Wiley Online Library
… , several … three therapeutic targets (proteases: RNA-dependent RNA polymerase [RdRp],
main protease [M pro ], and papain-like protease [PL pro ]; Figure 1) and relevant potential …
main protease [M pro ], and papain-like protease [PL pro ]; Figure 1) and relevant potential …
Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
… develop therapeutic strategies that target severe … multiple successful vaccines in an
exceptionally rapid time frame 3,4 , as well as the evaluation of a wide range of potential treatments …
exceptionally rapid time frame 3,4 , as well as the evaluation of a wide range of potential treatments …
Neutrophil extracellular traps (NETs) and damage‐associated molecular patterns (DAMPs): two potential targets for COVID‐19 treatment
S Cicco, G Cicco, V Racanelli… - Mediators of …, 2020 - Wiley Online Library
… In fact, as we point out in this review, NETosis and DAMPs appear to be two promising
treatment targets. In this view, to obtain a better control of inflammation in COVID-19 patients, it …
treatment targets. In this view, to obtain a better control of inflammation in COVID-19 patients, it …
COVID-19 associated complications and potential therapeutic targets
JD Monpara, SJ Sodha, PK Gupta - European Journal of Pharmacology, 2020 - Elsevier
… complications in COVID-19 and potential therapies under investigation. Several treatments
are … Several potential treatments are under investigation and is discussed in this review by …
are … Several potential treatments are under investigation and is discussed in this review by …
[HTML][HTML] COVID-19 signalome: Potential therapeutic interventions
K Lundstrom, A Hromić-Jahjefendić, E Bilajac… - Cellular signalling, 2023 - Elsevier
… In this review, we expand the spectrum of SARS-CoV-2 targets by investigating the COVID-19
… RdRp is a potential target as it is most conserved across several viral species including …
… RdRp is a potential target as it is most conserved across several viral species including …
Heparin–an old drug with multiple potential targets in Covid‐19 therapy
U Lindahl, JP Li - Journal of Thrombosis and Haemostasis, 2020 - jthjournal.org
… Effects of potential value in Covid‐19 treatment include prevention of viral adhesion but
also anti‐inflammatory activity based on inhibition of neutrophil chemotaxis and leukocyte …
also anti‐inflammatory activity based on inhibition of neutrophil chemotaxis and leukocyte …
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