… Despite the drawbacks that this approach still has to challenge, the appearance of multi-target
drugs has inflated new enthusiasm in the field of targeted therapy: after the …

… of multitarget therapies and the most relevant results obtained in different cancer types. …
demonstrate a wide spectrum of activity of multitarget drugs in different cancer types ( Table 1 ), …

… single-target drugs, applied as co-therapy regimens or, in many … therapeutic approaches
to obtain multi-target modulation in oncology. However, the risk of increased toxicity of the drug …

… We introduce here the first multi-target approach for the design and prediction of anti-PCa
agents against several cell lines. Here, a fragment-based QSAR model was developed. The …

… could impact cancer development and … cancer therapy and the most encouraging drugs
under study, focusing on the rationale behind their usage to improve efficacy of classic therapy …

… We introduce here the first Chemoinformatics multi-target approach for the in silico design
and prediction of anti-BT agents against several cell lines. Here, a fragment-based QSAR …

… For example, most of the targets for cancer therapy, such as different types of tyrosine kinase,
were clustered in the left panel, whereas most of the nervous-system-related targets, such …

… The anti-cancer drug discovery paradigm “one-compound-one-target” has failed and
subsequently shifted to two-drug cocktail and recently the “multi-target approach” in order to design …

… The increasingly evident limitations of target-selective cancer therapy … therapy failure from
which target-selective drugs are not exempt. A widely proposed approach to conquer therapy …

… of multitarget therapy, especially dual-target therapy, has become a hot research field of
cancer therapy, which may provide an effective strategy with higher therapeutic efficacy, …