Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases
… Our evaluation of the current literature suggests the potential of gossypol and its
derivatives as multitargeting drug candidates to combat multiple human malignancies. …
derivatives as multitargeting drug candidates to combat multiple human malignancies. …
Phytochemicals as multi-target inhibitors of the inflammatory pathway-A modeling and experimental study
NS Devi, M Ramanan, P Paragi-Vedanthi… - … and biophysical research …, 2017 - Elsevier
… Phytochemicals (such as curcumin) have been shown to have multi-targeted action against
… The possible candidates identified by this study are experimentally tested against the two …
… The possible candidates identified by this study are experimentally tested against the two …
Curcumin, a multitarget phytochemical: challenges and perspectives
HJ Wiggers, S Zaioncz, J Cheleski… - Studies in Natural …, 2017 - Elsevier
… drug candidates in order to block HIV-1 replication [86]. Curcumin and its derivatives,
namely, reduced curcumin, allyl-curcumin, and tocopheryl-curcumin, revealed 70 to 85 percent …
namely, reduced curcumin, allyl-curcumin, and tocopheryl-curcumin, revealed 70 to 85 percent …
[HTML][HTML] Screening of phytochemicals as potential inhibitors of breast cancer using structure based multitargeted molecular docking analysis
V Jha, S Devkar, K Gharat, S Kasbe, DK Matharoo… - Phytomedicine …, 2022 - Elsevier
… For initial screening, SwissADME (http://www.swissadme.ch/ ), an online web-based
platform, was used, which evaluates the pharmaceutical fidelity of the drug candidates. Various …
platform, was used, which evaluates the pharmaceutical fidelity of the drug candidates. Various …
Phytochemicals: a multitargeted approach to gynecologic cancer therapy
L Farrand, SW Oh, YS Song… - BioMed research …, 2014 - Wiley Online Library
… If this framework is implemented, considerable flexibility will be conferred to the
pharmaceutical industry in the development and clinical testing of new drug candidates. The …
pharmaceutical industry in the development and clinical testing of new drug candidates. The …
Computational evaluation of phytocompounds for combating drug resistant tuberculosis by multi-targeted therapy
S Sundarrajan, S Lulu, M Arumugam - Journal of molecular modeling, 2015 - Springer
… of phytochemicals of our work was restricted to compounds whose activity had been proved
against M.tuberculosis. The phytochemicals … from the candidate list, drug score and toxicity …
against M.tuberculosis. The phytochemicals … from the candidate list, drug score and toxicity …
Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy
T Efferth, E Koch - Current drug targets, 2011 - ingentaconnect.com
… multi-targeted compound complexes. … phytochemicals and proteins such as enzymes and
receptors have common evolutionary roots. Hence, the probability to find new drug candidates …
receptors have common evolutionary roots. Hence, the probability to find new drug candidates …
[PDF][PDF] Multitargeted molecular docking study of phytochemicals on hepatocellular carcinoma
V Jha, A Bhosale, P Kapadia, A Bhargava, A Marick… - 2022 - researchgate.net
… : Sorgolactone and Alectrol, emerged as the most befitting drug candidates against …
phytochemicals can be explored and exploited further for their use as potential HCC drug candidates…
phytochemicals can be explored and exploited further for their use as potential HCC drug candidates…
Novel phytochemical–antibiotic conjugates as multitarget inhibitors of Pseudomononas aeruginosa GyrB/ParE and DHFR
P Jayaraman, KR Sakharkar, CS Lim… - Drug Design …, 2013 - Taylor & Francis
… that they are promising drug candidates with drug-like pharmacotherapeutic profiles. In …
the common pharmacophoric features required for multitarget inhibition. Furthermore, docking …
the common pharmacophoric features required for multitarget inhibition. Furthermore, docking …
Neuroprotection of Multitargeted Phytochemicals against Alzheimer: A Desperate Need from Nature
AK Dhingra, B Chopra - The Natural Products Journal, 2023 - ingentaconnect.com
… Because of multi-targeted pharmacological activities, resveratrol could be a potential lead
compound for the development of anti-AD candidates. However, the clinical information is …
compound for the development of anti-AD candidates. However, the clinical information is …