Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases

D Pal, P Sahu, G Sethi, CE Wallace, A Bishayee - Pharmaceutics, 2022 - mdpi.com
… Our evaluation of the current literature suggests the potential of gossypol and its
derivatives as multitargeting drug candidates to combat multiple human malignancies. …

Phytochemicals as multi-target inhibitors of the inflammatory pathway-A modeling and experimental study

NS Devi, M Ramanan, P Paragi-Vedanthi… - … and biophysical research …, 2017 - Elsevier
Phytochemicals (such as curcumin) have been shown to have multi-targeted action against
… The possible candidates identified by this study are experimentally tested against the two …

Curcumin, a multitarget phytochemical: challenges and perspectives

HJ Wiggers, S Zaioncz, J Cheleski… - Studies in Natural …, 2017 - Elsevier
drug candidates in order to block HIV-1 replication [86]. Curcumin and its derivatives,
namely, reduced curcumin, allyl-curcumin, and tocopheryl-curcumin, revealed 70 to 85 percent …

[HTML][HTML] Screening of phytochemicals as potential inhibitors of breast cancer using structure based multitargeted molecular docking analysis

V Jha, S Devkar, K Gharat, S Kasbe, DK Matharoo… - Phytomedicine …, 2022 - Elsevier
… For initial screening, SwissADME (http://www.swissadme.ch/ ), an online web-based
platform, was used, which evaluates the pharmaceutical fidelity of the drug candidates. Various …

Phytochemicals: a multitargeted approach to gynecologic cancer therapy

L Farrand, SW Oh, YS Song… - BioMed research …, 2014 - Wiley Online Library
… If this framework is implemented, considerable flexibility will be conferred to the
pharmaceutical industry in the development and clinical testing of new drug candidates. The …

Computational evaluation of phytocompounds for combating drug resistant tuberculosis by multi-targeted therapy

S Sundarrajan, S Lulu, M Arumugam - Journal of molecular modeling, 2015 - Springer
… of phytochemicals of our work was restricted to compounds whose activity had been proved
against M.tuberculosis. The phytochemicals … from the candidate list, drug score and toxicity …

Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy

T Efferth, E Koch - Current drug targets, 2011 - ingentaconnect.com
multi-targeted compound complexes. … phytochemicals and proteins such as enzymes and
receptors have common evolutionary roots. Hence, the probability to find new drug candidates

[PDF][PDF] Multitargeted molecular docking study of phytochemicals on hepatocellular carcinoma

V Jha, A Bhosale, P Kapadia, A Bhargava, A Marick… - 2022 - researchgate.net
… : Sorgolactone and Alectrol, emerged as the most befitting drug candidates against …
phytochemicals can be explored and exploited further for their use as potential HCC drug candidates

Novel phytochemical–antibiotic conjugates as multitarget inhibitors of Pseudomononas aeruginosa GyrB/ParE and DHFR

P Jayaraman, KR Sakharkar, CS Lim… - Drug Design …, 2013 - Taylor & Francis
… that they are promising drug candidates with drug-like pharmacotherapeutic profiles. In …
the common pharmacophoric features required for multitarget inhibition. Furthermore, docking …

Neuroprotection of Multitargeted Phytochemicals against Alzheimer: A Desperate Need from Nature

AK Dhingra, B Chopra - The Natural Products Journal, 2023 - ingentaconnect.com
… Because of multi-targeted pharmacological activities, resveratrol could be a potential lead
compound for the development of anti-AD candidates. However, the clinical information is …