… Our results suggest that absence of adequate Ca 2+ signaling through nuclear CaMKII …
nucleus, binds nuclear envelope IP 3 Rs that locally release Ca 2+ and activate nuclear CaMKII. …

… heart failure, we provide compelling evidence for structural and functional changes of the
nuclear envelope and nuclear Ca 2… immunostaining in either murine or human failing myocytes …

… contractility in murine myocardium by cAMP-dependent modulation of Ca 2+ transients, …
Consistent with our isolated heart studies, Figure 3 and Online Table II establish that Ca 2+ …

… of nuclear fractions from 1-day WT and homozygous hearts. … SR Ca 2+ release increased
the activity of calcineurin, a Ca 2… that through dephosphorylation of nuclear factor of activated T …

… in heart, and cardiomyocytes express not only the nuclear … Ca 2+ regulatory proteins and
induce hypertrophy or heart failure, … , Ohio) between the 5.5-kb murine α-MHC promoter and a …

… To determine whether the observed mitochondrial Ca 2+ overload in failing hearts can
be caused by SR Ca 2+ leak via RyR2, we used a murine model harboring a mutation that …

… Results Western blots of rat heart nuclear fractions and confocal immunofluorescent … , not
the β 2 AR on nuclear membranes. Nuclear localization of downstream signalling partners Gs, …

… -operated Ca 2+ entry, and this sustained Ca 2+ entry mechanism is necessary for NFAT
nuclear … overexpression in the mouse heart substantially enhances store-operated Ca 2+ entry. …

… more nuclear translocation of p65, a component of nuclear factor-… This Ca 2+ can elevate
local Ca 2+ concentration in EPI … by the mechanism named as Ca 2+ -induced Ca 2+ channel …

… single myocyte [Ca 2+ ] i transients in the intact left ventricle of a mouse heart loaded with …
-μm section from a heart loaded with rhod-2 and the nuclear counterstain Hoechst 34580. Note …