… We previously demonstrated that uridine adenosine … muscle cells (SMC). We further
investigated whether activation of A 2B R is involved in Up 4 A-mediated coronary SMC relaxation. …

… Now, we will continue the discussion of the other steps in the downstream cascade from
CYPs until the hyperpolarization which ultimately leads to vascular smooth muscle relaxation. In …

… Also, our results suggest that endothelium-dependent relaxation of RRA in response to
adenosine is notably dependent upon activation of smooth muscle K ATP channels. Finally, this …

… of these antinicotinic drugs partially attenuates muscle relaxation by increasing the safety …
of adenosine through the equilibrative transport system, 17 then proposing that adenosine, …

… muscle strips at each concentration of adenosine (note: for a single adenosine concentration,
each muscle … observed in the overall group data for adenosine, however, dose–response …

… 2 adenosine receptors exist on the smooth muscle and endothelium of porcine coronary artery,
mediating relaxation … Further studies from this laboratory have also shown that adenosine …

… These medications, however, are plagued by a wide range of adverse effects, including
muscle relaxation, rebound insomnia, changes in appetite, next-day sedation, cognitive …

… consisted of a muscular relaxation with an amplitude 70% of the relaxation induced by 0.1 …
submaximal dose of adenosine (30 µM), indicating that adenosine-induced relaxation was not …

… To investigate relaxation mechanisms for ATP and adenosine … muscle contraction via P2X
receptors, whereas relaxation is … may also induce relaxation via breakdown to adenosine. …

… -dependent relaxation (maximum of 25% and 28% relaxation at 10 −5 M … relaxation in both
KO and WT tissues. In conclusion, A 2A AR KO mice had significantly lower aortic relaxation …