… 1Pathophysiological flow chart of the muscular dystrophies showing the pathological
cascades initiated by dystrophin … Many biochemical, physiological and molecular studies have …

… pathophysiological cascades in the muscular dystrophies. We felt that the muscular dystrophies
… First, muscle is a relatively simple tissue, with the myofiber being the predominant cell …

… 1), was a major breakthrough and the first step taken towards clarification of the molecular
pathogenesis of muscular dystrophy. The DGC is a multisubunit complex47,136 of proteins …

… role in muscle function, the muscular dystrophy pathology is … feline muscular dystrophy
exhibit a muscle pathology similar … Nonmammalian models of dystrophic pathology such as …

… pathogenesis of these diseases is being used for the development of novel therapies. In the
most common form, Duchenne muscular dystrophy… manifestations, molecular pathogenesis, …

… This review consolidates what is known regarding molecular pathology of the DMD heart, …
development to restore dystrophin thereby improving pathology, with a focus on the heart. …

… pathogenesis. … of muscle dystrophin also prevent the production of two other full-length
and, depending on the location of the mutation, one or more shorter brain isoforms of dystrophin. …

Duchenne muscular dystrophy (DMD) is caused by mutations in the gene that encodes the …
protein dystrophin. Increased knowledge of the function of dystrophin and its role in muscle …

… These forms of muscular dystrophy feature both skeletal muscle wasting … of muscular
dystrophy is Duchenne muscular dystrophy (DMD), which arises due to mutations in the dystrophin …

… understanding of the molecular pathogenesis of several … This knowledge has helped identify
molecular and biochemical … understanding of the molecular pathogenesis of several CMD …