… In SARS-CoV-2, we find evidence for common intrahost purifying … Indeed, the volume of
genome data for SARS-CoV-2 allows an … Similarly, mutational scanning experiments indicate …

… of RBM mutations on each of the binding clusters in SARS-CoV-2 by using two in silico
approaches: structural modelling and mutagenesis (Fig. 3B, C and Additional File 1: Table S1). …

… and perturbation-response scanning of the SARS-CoV-2 spike … We suggest that the
SARS-CoV-2 S protein may exploit the … mutagenesis have quantified binding mechanisms of …

… as indicated in the alanine scan. When mutating G26 into … zero or even negative from the
alanine scan (Fig. 2e) should be … FEP calculations for alanine scan and enumerated mutations, …

… Alanine scanning mutagenesis on SARS-CoV-2-RBD showed a defined epitope for the
CR3022 antibody. All sites that emerged from the scanning mutagenesis aligned within close …

… Binding energy change (ΔΔG = ΔG WILD-TYPE – ΔG ALA ) obtained from the computational
alanine-scanning (CAS) mutagenesis for the S-RBD CoV‑2 residues at the binding …

… in SARS-CoV has been characterized in cultured mammalian cells using a dual luciferase
reporter system and mass spectrometry. Mutagenic analysis of the SARS-CoV … was scanned …

… To determine the potential for mutations to arise that disrupt LCB1 and AHB2 binding to the
RBD, we performed deep mutational scans using site saturation mutagenesis of the RBD (38)…

… A summary of data on SARS CoV-2 mutations worldwide from December 2019 to June …
easier by cutting-edge technology like alanine scanning and machine learning. DeepNEU, a type …

… scanning approach to systematically profile the activity of all possible single mutants of the
SARS-CoV-… In general, the structural insights support the results from our mutagenesis study, …