… of adult neural stem cells and, we discuss how the loss of p53 and deregulation of growth …
Mutant p53 protein was detectable in a minority of proliferative neural stem cells two months …

… p53 in brain development, neural stem cell regulation and the mechanisms of inactivating
p53 … Loss of p53 function and gain-of-function of mutant p53 are both implicated in brain …

… detectable level of mutant p53 proteins occurs first in neural stem cells in the subventricular
… expansion of mutant p53-expressing Olig2 + transit-amplifying progenitor-like cells in the SVZ…

… The mutations that inactivate p53 function in cancer cells … p53 protein and produce a protein
that fails to transcribe p53-… the p53 pathway in adult neural stem and progenitor cells in vivo …

… that p53 mRNA levels and promoter activity are increased during neuronal progenitor cell …
We also found that p53 protein levels went down from day 15.5 and were almost undetectable …

… of spontaneous GBM require mutant/dysfunctional p53. In a mouse model using conditionally
inactivated p53 in the brain, tumors developed from neural progenitor cells (NPC) in the …

… Gli1 and p53 form a reciprocal inhibitory loop. Hh signal through Gli1 activates the E3
Ligase Mdm2, which degrades p53 protein, thus relieving its inhibitory activities on both Nanog …

… Mouse neural stem cells used in this study were obtained from Dr. Reynold's Laboratory
at the University of Queensland, Brisbane, Australia, and provided by Dr. Low's Laboratory at …

… rates and timing of neural stem cell (NSC) proliferation, neurogenesis and cell death. The
cellular mechanisms connecting genetic mutations to brain malformation phenotypes are still …

… p53 suppresses whereas GLI1 promotes tumourigenesis. We report that (1) the level of
GLI1 determines the number of neural stem cells in vivo, (2) GLI1 and p53 … in a p53-dependent …