… was involved in the regulation of neural stem/progenitor cells (NPCs). However, distinct
function of each family member was reported in regulating stem cells within and without the brain…

… Here, we show that ablating Pten in adult neural stem cells in the subgranular zone of …
differentiation of the stem/progenitor cells, leading to depletion of the neural stem cell pool and …

… neural progenitor cell homeostasis and imply a role for p53 in the fine-tuning of progenitor
cell ROS … Indeed, elevation in ROS in embryonic p53-/- neural progenitor cells may provide a …

… of an undifferentiated neural precursor cell phenotype. p53MYC astrocytes additionally
expressed CD133, Olig2 and Musashi-1 which are considered to be neural stem cell (NSC) …

… mechanism that protects stem/progenitor cells from spontaneous … neural-specific deletion
of NS increases the frequency of spontaneous DNA damage and eliminates neural stem cells (…

… Continual generation of new neural cells from adult neural stem/progenitor cells (NPCs) is
an important component of life-long brain plasticity. However, the intrinsic regulation of this …

… in brain cancer-initiating neural stem cells, we undertook an unbiased approach to identify
proteins that preferentially interact with BMI1 in CD133+ cells after acute DNA damage. GBM …

… the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells.
The … , other compounds, interfering RNAs, or antibodies specifically targeting the mutant p53 …

… between neural stem cells, progenitor cells, and differentiated cells is illustrated… neural stem
cells as well as mature astrocytes in the postnatal brain (all three hGFAP-cre-expressing cell …

… PTEN is a tumour suppressor frequently mutated in many … neural stem cells (NSCs), but
not mesenchymal stem cells. … element binding protein 1 (CREB)/CREB binding protein (CBP) …