… of urothelial carcinomas with increased tumor mutation burden (TMB) … bladder carcinomas
from The Cancer Genome Atlas (TCGA) [11]. Genomic data from the TCGA bladder carcinoma …

… Background: Bladder cancer is the ninth most-common cancer worldwide and it is
associated with high morbidity and mortality. Tumor mutational burden (TMB) is an emerging …

… 18 CDKN1A-mutant bladder cancers of a total of 130 analysed 13 . We conclude that
CDKN1A is a tumour suppressor gene in bladder carcinoma, and we note that its inactivation is a …

… , we observed that EP300 mutation upregulated signaling pathways … is frequently mutated
in bladder cancer, and its mutation is … cell carcinoma of the head and neck [21, 22]. Specific …

… (NSCLC), which typically have high mutation burden owing to the mutagenic effects of ultraviolet
… that include renal cell carcinoma and Merkel cell carcinoma that responded better than …

… from carcinoma in situ followed driver mutations in NA13/FAT1… more diverse mutational
trajectory of bladder tumorigenesis … contributor to the mutational burden of bladder cancer 23, 35 …

… tract urothelial carcinomas and probably also cases of bladder … In this hereditary disease,
mutations in mismatch repair … overall mutational burden is much higher in MIBC (>7 mutations …

… Bladder cancer (BLCA) is the most common carcinoma in the urinary system and remains
a major global medical problem despite the numerous new treatment options available, BLCA …

… Urothelial carcinoma is characterized by a high total mutational burden of >7 mutations per
… Compared with other solid tumours, the high mutational burden in urothelial carcinoma might …

… carcinoma with areas of squamous differentiation characterized by very high tumor mutational
burden (TMB)… Additionally, molecular analysis revealed somatic mutations in several other …