Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum

JR Jass, H Iino, A Ruszkiewicz, D Painter, MJ Solomon… - Gut, 2000 - gut.bmj.com
… changes in hyperplastic polyposis may occur within a hyperplastic polyp. Neoplasia may …
mutator pathways drive neoplasia in hyperplastic polyposis. The role of the hyperplastic polyp

DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?

H Iino, JR Jass, LA Simms, J Young, B Leggett… - Journal of Clinical …, 1999 - jcp.bmj.com
… sided hyperplastic polyps are the condition hyperplastichyperplastic polyps, serrated
adenomas, and mixed polyps were more likely to show MSI in females. Furthermore, MSI polyps

[HTML][HTML] A serrated colorectal cancer pathway predominates over the classic WNT pathway in patients with hyperplastic polyposis syndrome

KS Boparai, E Dekker, MM Polak, AR Musler… - The American journal of …, 2011 - Elsevier
… , microsatellite-instability (MSI) pathway exists that is characterized by deletion or … pathway
has been proposed that involves the progression of serrated polyps, ie, hyperplastic polyps (…

Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway

CS Huang, MJ O'brien, S Yang… - Official journal of the …, 2004 - journals.lww.com
hyperplastic polyps (HPs) and their putative successor lesions, serrated adenomas (SAs),
and to discuss their role in alternative pathways … “mild mutator”MSI-Low (MSI-L) pathway has …

Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum

JR Jass, J Young, BA Leggett - Histopathology, 2000 - Wiley Online Library
… Given that a subset of hyperplastic polyps will be primed with the MSI-L phenotype (albeit …
, the subsequent loss of hMLH1 expression may rapidly establish the high mutator pathway. …

Hyperplastic polyps and colorectal cancer: is there a link?

JR Jass - Clinical Gastroenterology and Hepatology, 2004 - Elsevier
hyperplastic polyps. The aim of this review is to synthesize recent evidence regarding the role
of hyperplastic polyps … steps in 3 pathways to ACF, hyperplastic polyp and hyperplastic-like …

Colorectal carcinomas arising in the hyperplastic polyposis syndrome progress through the chromosomal instability pathway

NJ Hawkins, P Gorman, IPM Tomlinson… - The American journal of …, 2000 - Elsevier
hyperplastic polyposis syndrome associated with two synchronous carcinomas, one of which
arises within a pre-existing hyperplastic … , or mutator phenotype pathway. Importantly, it has …

Hyperplastic polyps of the colorectum—innocent or guilty?

JR Jass - Diseases of the colon & rectum, 2001 - journals.lww.com
… of hyperplastic polyp, particularly large hyperplastic polyps … frequently observed in small
hyperplastic polyps occurring in … occurs through mutator pathways in hyperplastic polyposis of …

Hyperplastic polyps in hereditary nonpolyposis colorectal cancer

FEM Rijcken, T Van Der Sluis, H Hollema… - Official journal of the …, 2003 - journals.lww.com
Hyperplastic polyps (HP) may serve as precursor for these MSI … to examine whether
hyperplastic polyps are also possible … , and mixed polyps: A mild mutator pathway for colorectal …

Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways.

JR Jass, KG Biden, MC Cummings, LA Simms… - Journal of clinical …, 1999 - jcp.bmj.com
… types of colorectal polypshyperplastic polyps, serrated adenomas, and mixed polyps.We …
is driven by a combined suppressor and mild mutator mechanism.In order to test this …