High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/akt pathway in thyroid tumors

Y Wang, P Hou, H Yu, W Wang, M Ji… - The Journal of …, 2007 - academic.oup.com
Mutual exclusivity was seen among all these PI3K/Akt pathway-related genetic alterations
in all thyroid tumors … a significant role in the pathogenesis of thyroid tumors, particularly FTC. …

Early Occurrence of RASSF1A Hypermethylation and Its Mutual Exclusion with BRAF Mutation in Thyroid Tumorigenesis

M Xing, Y Cohen, E Mambo, G Tallini, R Udelsman… - Cancer research, 2004 - AACR
… early step in thyroid tumorigenesis. Like the previously reported mutually exclusive relationship
… Our findings on RASSF1A hypermethylation in thyroid tumors are interesting for several …

Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS

N Agrawal, Y Jiao, M Sausen, R Leary… - The Journal of …, 2013 - academic.oup.com
… in RET mutation-negative tumors. The RET, KRAS, and HRAS mutations observed in MTC
were mutually exclusive and collectively found in the vast majority of the tumors (Table 1). RET…

Co-occurrence and mutual exclusivity: what cross-cancer mutation patterns can tell us

G El Tekle, T Bernasocchi, AM Unni, F Bertoni, D Rossi… - Trends in cancer, 2021 - cell.com
tumor types or genetic backgrounds. Here, we review examples of co-occurring and mutually
exclusive … of incompatibilities among the mutually exclusive driver genes depending on …

Thyroid cancer under the scope of emerging technologies

M Tarabichi, P Demetter, L Craciun, C Maenhaut… - Molecular and cellular …, 2022 - Elsevier
Thyroid tumors may originate from follicular thyroid cells or parafollicular cells (C cells),
which … The majority of PTCs present three genetic alterations which are mutually exclusive: …

[HTML][HTML] Immune landscape of thyroid cancers: new insights

E Menicali, M Guzzetti, S Morelli, S Moretti… - Frontiers in …, 2021 - frontiersin.org
… Focusing on thyroid tumor, this review wants to provide a comprehensive and updated view
… As mentioned above, PTC is a MAPK-driven cancer that has three major mutually exclusive

A weighted exact test for mutually exclusive mutations in cancer

MDM Leiserson, MA Reyna, BJ Raphael - Bioinformatics, 2016 - academic.oup.com
… We introduce a new weighted test for mutual exclusivity that … mutual exclusivity, which we
refer to as the row exclusivity (R-exclusivity) and row-column exclusivity (RC-exclusivity) tests. …

[HTML][HTML] How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy

JA Fagin - Journal of Endocrinology, 2004 - joe.bioscientifica.com
… Recent analysis of human papillary thyroid cancers demonstrate the presence of mutually
exclusive mutations of either RET/PTC, RAS or BRAF, with little overlap between them, …

Diagnosis and management of differentiated thyroid cancer using molecular biology

RL Witt, RL Ferris, EA Pribitkin, SI Sherman… - The …, 2013 - Wiley Online Library
… These mutations are also mutually exclusive and identified in 70% of … of thyroid neoplasia,
and to detect genetic markers that could improve the differential diagnosis of thyroid tumors. …

Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability

Y Deng, S Luo, C Deng, T Luo, W Yin… - Briefings in …, 2019 - academic.oup.com
mutual exclusivity and associated approaches, we present an overview of mutual exclusivity
… First of all, we briefly describe possible hypotheses underlying mutual exclusivity. Then, we …