High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/akt pathway in thyroid tumors
Y Wang, P Hou, H Yu, W Wang, M Ji… - The Journal of …, 2007 - academic.oup.com
… Mutual exclusivity was seen among all these PI3K/Akt pathway-related genetic alterations
in all thyroid tumors … a significant role in the pathogenesis of thyroid tumors, particularly FTC. …
in all thyroid tumors … a significant role in the pathogenesis of thyroid tumors, particularly FTC. …
Early Occurrence of RASSF1A Hypermethylation and Its Mutual Exclusion with BRAF Mutation in Thyroid Tumorigenesis
M Xing, Y Cohen, E Mambo, G Tallini, R Udelsman… - Cancer research, 2004 - AACR
… early step in thyroid tumorigenesis. Like the previously reported mutually exclusive relationship
… Our findings on RASSF1A hypermethylation in thyroid tumors are interesting for several …
… Our findings on RASSF1A hypermethylation in thyroid tumors are interesting for several …
Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS
… in RET mutation-negative tumors. The RET, KRAS, and HRAS mutations observed in MTC
were mutually exclusive and collectively found in the vast majority of the tumors (Table 1). RET…
were mutually exclusive and collectively found in the vast majority of the tumors (Table 1). RET…
Co-occurrence and mutual exclusivity: what cross-cancer mutation patterns can tell us
… tumor types or genetic backgrounds. Here, we review examples of co-occurring and mutually
exclusive … of incompatibilities among the mutually exclusive driver genes depending on …
exclusive … of incompatibilities among the mutually exclusive driver genes depending on …
Thyroid cancer under the scope of emerging technologies
M Tarabichi, P Demetter, L Craciun, C Maenhaut… - Molecular and cellular …, 2022 - Elsevier
… Thyroid tumors may originate from follicular thyroid cells or parafollicular cells (C cells),
which … The majority of PTCs present three genetic alterations which are mutually exclusive: …
which … The majority of PTCs present three genetic alterations which are mutually exclusive: …
[HTML][HTML] Immune landscape of thyroid cancers: new insights
E Menicali, M Guzzetti, S Morelli, S Moretti… - Frontiers in …, 2021 - frontiersin.org
… Focusing on thyroid tumor, this review wants to provide a comprehensive and updated view
… As mentioned above, PTC is a MAPK-driven cancer that has three major mutually exclusive …
… As mentioned above, PTC is a MAPK-driven cancer that has three major mutually exclusive …
A weighted exact test for mutually exclusive mutations in cancer
… We introduce a new weighted test for mutual exclusivity that … mutual exclusivity, which we
refer to as the row exclusivity (R-exclusivity) and row-column exclusivity (RC-exclusivity) tests. …
refer to as the row exclusivity (R-exclusivity) and row-column exclusivity (RC-exclusivity) tests. …
[HTML][HTML] How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy
JA Fagin - Journal of Endocrinology, 2004 - joe.bioscientifica.com
… Recent analysis of human papillary thyroid cancers demonstrate the presence of mutually
exclusive mutations of either RET/PTC, RAS or BRAF, with little overlap between them, …
exclusive mutations of either RET/PTC, RAS or BRAF, with little overlap between them, …
Diagnosis and management of differentiated thyroid cancer using molecular biology
RL Witt, RL Ferris, EA Pribitkin, SI Sherman… - The …, 2013 - Wiley Online Library
… These mutations are also mutually exclusive and identified in 70% of … of thyroid neoplasia,
and to detect genetic markers that could improve the differential diagnosis of thyroid tumors. …
and to detect genetic markers that could improve the differential diagnosis of thyroid tumors. …
Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability
Y Deng, S Luo, C Deng, T Luo, W Yin… - Briefings in …, 2019 - academic.oup.com
… mutual exclusivity and associated approaches, we present an overview of mutual exclusivity
… First of all, we briefly describe possible hypotheses underlying mutual exclusivity. Then, we …
… First of all, we briefly describe possible hypotheses underlying mutual exclusivity. Then, we …
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