… of c-Myc and therapeutic strategies against cancer using small molecules targeting the …
, in particular G-quadruplexes formed in c-Myc promoter and c-Myc/Max dimerization. Such …

… In disease states, studies have shown that aberrant MYC expression results in promoter
invasion, with MYC binding to both high- and low-affinity consensus sequences, altering the …

… of all 3 forms of MYC to their target promoters, has been shown to … targeting MYC has yet
progressed to clinical testing, APTO-253, which partly acts by decreasing expression of MYC, is …

… important insights into targeting the major G4 of the MYC promoter by small molecules. The
newly … It has drug-like properties with low molecular weight, which makes it a promising lead-…

… MYC expression is complex and involves multiple promoters and transcriptional start sites.
P1 and P2 seem to be the predominant promoters … -MYC promoter controls 85–90% of c-MYC …

… rate of the c-Myc promoter, we provide a more complete picture of how c-Myc transcription is
likely … as novel mechanisms for small molecule targeting of transcriptional control of c-Myc. …

… MYC expression that involves a four-stranded DNA structure, termed a G-quadruplex, amenable
to small molecule targeting. … the NHE III 1 in the MYC promoter are the closest thing that …

… can precisely control the rate of MYC promoter firing. NHE III 1 … to suppress MYC expression
by small-molecule targeting of … of MYC in cancer and its attractiveness as a therapeutic target…

… Furthermore, the c-myc promoter integrates diverse mitogenic signalling cascades, which
are constitutively activated in tumor cells, and translates them into expression of the c…

… In prostate and breast cancer cell lines, TFOs targeting the P2 promoter of c-myc can lead
to growth inhibition and apoptosis when covalently linked to the DNA-intercalating agent …