T-cell-mediated protection of mice against virulent Mycobacterium tuberculosis

…, B Champion, S Lucas, B De Souza, M Nicol… - Infection and …, 1989 - Am Soc Microbiol
… We sought to protect CBA mice against tuberculosis using in vivo transfer of a T-cell line …
vitro with Mycobacterium tuberculosis. This line induces total bacteriostasis in vitro. In mice that …

Enhanced protection to Mycobacterium tuberculosis infection in IL‐10‐deficient mice is accompanied by early and enhanced Th1 responses in the lung

PS Redford, A Boonstra, S Read, J Pitt… - European journal of …, 2010 - Wiley Online Library
… show here that Mycobacterium tuberculosis (Mtb) infection in the absence of IL-10 (IL-10 −/−
mice) … of Mtb-infected mice. This suggests that IL-17 may contribute to dissemination of Mtb. …

The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs

C Martin, A Williams, R Hernandez-Pando, PJ Cardona… - Vaccine, 2006 - Elsevier
… Both protein and DNA vaccines induce partial protection against experimental tuberculosis
infection in mice, however, their efficacy has generally been equivalent to or less than that …

Mycobacterium tuberculosis‐activated dendritic cells induce protective immunityin mice

RE Tascon, CS Soares, S Ragno, E Stavropoulos… - …, 2000 - Wiley Online Library
… Recently, BCG-infected DC were shown to protect mice against an aerosol challenge with
M. tuberculosis; 16 however, in these experiments the DC were given intratracheally a route …

Tumor necrosis factor-α is required in the protective immune response against Mycobacterium tuberculosis in mice

JAL Flynn, MM Goldstein, J Chan, KJ Triebold, K Pfeffer… - Immunity, 1995 - cell.com
… are essential for protection against tuberculosis in mice, and for … mice, but necrosis was
observed only in mice deficient in … necessary conditions for protection against murine M. fuberculo…

Mycobacterium tuberculosis arabinomannan–protein conjugates protect against tuberculosis

B Hamasur, M Haile, A Pawlowski, U Schröder… - Vaccine, 2003 - Elsevier
… subcutaneous immunization with the AMOs–antigen 85B conjugate in alum provided
significant protection compared to sham (alum only) immunized mice (P<0.021) as estimated by …

Mycobacterium tuberculosis ΔRD1 ΔpanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against …

…, T Hsu, B Chen, MH Larsen, KV Jalapathy, M Chen… - Vaccine, 2006 - Elsevier
mouse model showed that the anti-tuberculosis protectionprotection seen after immunization
of CD4 −/− mice with the … 2 6030-induced protection of CD4 −/− mice against a tuberculous …

Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins

P Andersen - Infection and immunity, 1994 - Am Soc Microbiol
tuberculosis cells release protective antigens during growth. … Human tuberculosis caused
by Mycobacterium tuberculosis re… In the second series of protection experiments, the mice

Protection of mice from Mycobacterium tuberculosis by ID87/GLA-SE, a novel tuberculosis subunit vaccine candidate

HP Windish, MS Duthie, G Ireton, E Lucas… - Vaccine, 2011 - Elsevier
… -SE immunization reduces Mycobacterium tuberculosis bacterial burden in C57BL/6 mice. …
Two million people die from Mycobacterium tuberculosis (Mtb) infection each year and it is …

A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis

VK Sambandamurthy, X Wang, B Chen, RG Russell… - Nature medicine, 2002 - nature.com
… of Mycobacterium tuberculosis, newer control strategies in the form of a better vaccine could
decrease the global incidence of tuberculosis… conferred protection in C57BL/6J mice against …