… Apoptosis is a key pathologic feature in acute myocardial infarction and heart failure.
Experimental animal studies have shown beneficial effects of inhibiting apoptosis. Understanding …

… that caspase inhibitors can have a remarkably positive effect on infarcts size, cardiac
muscle death in the remote myocardium and LV remodeling in heart failure animal models. …

… In myocardium of dogs with chronic heart failure we have also shown a marked decrease
in mitochondrial respiratory parameters compared to normal dogs [65]. While requiring further …

… However, the cellular mechanisms responsible for the progressive deterioration of
myocardial function observed in heart failure remain unclear and may result from apoptosis (…

… caspase exclusively in the myocardium, we demonstrate that very low levels of myocyte …
apoptosis may be a mechanism of heart failure, we created transgenic mice in which heart …

… heart failure post myocardial infarction. We propose 2 major pathways that contribute to
development of heart failure following myocardial … can lead to myocardial apoptosis and myocyte …

… apoptosis is consistently present in end-stage heart failure in man. Importantly, apoptosis
occurs … Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Am J …

Objectives : The purpose of this study was to evaluate a potential correlation between apoptotic
rate (AR), post-infarction left ventricular (LV) remodeling, and clinical characteristics in …

… myocardial apoptosis. Cellular sources of · O 2 − include mitochondria, XO, and NAD(P)H
oxidase. Elevated · O 2 − production in heart failure … initiating or promoting apoptotic cascades. …

… of heart failure. This review will focus on the clinical relevance of apoptosis in human and
experimental heart failure and identify some of the progress made in myocardial anti-apoptotic …