Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges

A Saxena, I Russo, NG Frangogiannis - Translational Research, 2016 - Elsevier
… cascade as a therapeutic target in myocardial infarction. After … reaction, promising therapeutic
approaches targeting the … effective therapeutic approaches for patients with myocardial

Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - … and targeted therapy, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to go …

Cardiac metabolism as a driver and therapeutic target of myocardial infarction

CJ Zuurbier, L Bertrand, CR Beauloye… - Journal of cellular …, 2020 - Wiley Online Library
… current knowledge of important metabolic pathways as therapeutic targets to combat cardiac
IRI. … metabolic therapy against cardiac IRI seems to be the singular or combined targeting of …

Mitochondrial quality surveillance as a therapeutic target in myocardial infarction

H Zhu, S Toan, D Mui, H Zhou - Acta physiologica, 2021 - Wiley Online Library
Myocardial infarction (MI) is a leading cause of morbidity and … of therapeutic strategies
targeting mitochondrial homeostasis… the available therapeutic approaches targeting mitochondrial …

Macrophage polarization as a therapeutic target in myocardial infarction

Y Cheng, J Rong - Current Drug Targets, 2018 - ingentaconnect.com
… associated with cardioprotection after myocardial infarction [53]. Finally, PPAR is a potential
therapeutic target for the treatment of myocardial infarction. PPAR exhibits cardioprotective …

Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure

LC O'Brien, E Mezzaroma, BW Van Tassell… - Molecular …, 2014 - Springer
… decreased infarct size (64). These results show that IL-18 is increased after myocardial
infarction and … The mechanism by which IL-18 blockade reduces infarct size has not been fully …

Inflammatory response post-myocardial infarction and reperfusion: a new therapeutic target?

RF Bonvini, T Hendiri… - European Heart Journal …, 2005 - academic.oup.com
Inflammation is a cornerstone of the post-myocardial infarction healing process. However,
an exuberant systemic as well as loco-regional inflammatory response may have a direct …

SUMOylation as a therapeutic target for myocardial infarction

W Zhao, X Zhang, J Rong - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
myocardial infarction and identifies the potential treatments against myocardial injury via
targeting SUMO… Ultimately, this review recommends SUMOylation as a key therapeutic target for …

Fibrosis as a therapeutic target post-myocardial infarction

F See, A Kompa, J Martin, DA Lewis… - Current pharmaceutical …, 2005 - ingentaconnect.com
… to the adverse ventricular remodelling that follows myocardial infarction (MI), via activation
of … Therefore, reversal of this process represents an important therapeutic target in post-MI …

ICAM-1 in acute myocardial infarction: a potential therapeutic target

V Benson, A Clare McMahon… - Current molecular …, 2007 - ingentaconnect.com
… appear an important potential therapeutic target in this context, … myocardial endothelial cell
ICAM-1 suppression with AMI reduction mean ICAM-1 remains an attractive therapeutic target