… evidences indicate that m 6 A modification is strongly associated with drug resistance. In
the … m 6 A modification-associated drug resistance, as well as strategies targeting the m 6 A …

… changes in the m 6 A levels of these regulators are increasingly associated with human
tumorigenesis and drug resistance. However, the molecular mechanisms underlying m 6 A RNA …

… In order to determine the effect of 6mA modification on Olaparib drug resistance, we increased
ALKBH1 or decreased the expression of N6AMT1 in 231-RO cell lines (Figures 3A, B). …

… growth, metastasis and drug resistance emerge as therapeutic … Herein, we report that an N
6 -methyladenosine (m 6 A) at … 3 (METTL3), and this m 6 A-RNA promoted a preferential pre-…

… Intervention of RNA m6A methylation is a possible therapeutic strategy to overcome drug
resistance. Conclusions: RNA m6A methylation may play a crucial role in drug resistance …

… Moreover, m 6 A modification patterns have therapeutic implications and correlate with
drug resistance. HNRNPA2B1 and METTL3 overexpression in MCF-7 cells reduces their …

… N 6 -methyladenosine (m 6 A) is a … drug resistance of gastrointestinal stromal tumor (GIST)
is not known. Here, we report that m 6 A modification levels are elevated in imatinib-resistant …

… in multidrug resistance in CRC cells. Silencing of METTL3 suppresses the m6A formation
in p53 premRNA, thus abolishing oncogenic gain-of-function and sensitizing cells to several …

… factor for drug resistance in cancer. … -cancer drug resistance to facilitate cell survival and
that suppression of autophagy could enhance the sensitivity of cancer cells to anti-cancer drugs. …

… N 6 -methyladenosine (m 6 A) on mRNAs is critical for various biological processes, yet …
m 6 A regulates drug resistance remains unknown. Here we show that developing resistant …