NADPH oxidases: insights into selected functions and mechanisms of action in cancer and stem cells

M Skonieczna, T Hejmo… - Oxidative Medicine …, 2017 - Wiley Online Library
… , are NADPH oxidases (NOX). The physiological functions of NADPH oxidases are very …
Functions and mechanisms of action of NADPH oxidases in stem cells and cancer stem cells…

Inhibiting the activity of NADPH oxidase in cancer

MM Konaté, S Antony, JH Doroshow - Antioxidants & redox …, 2020 - liebertpub.com
… and could provide new therapeutic avenues for cancer treatment. At present, … of cancer.
Effectively, the number of publications in PubMed referencing “NADPH oxidase” and “cancer” …

Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets

IP Harrison, S Selemidis - Clinical and Experimental …, 2014 - Wiley Online Library
… Herein we emphasize the family of NADPH oxidase enzymes … pharmacological inhibitors
of NADPH oxidases and suggest … the use of NADPH oxidase inhibitors for cancer therapy, this …

NADPH oxidases and cancer

K Roy, Y Wu, JL Meitzler, A Juhasz, H Liu… - Clinical …, 2015 - portlandpress.com
… Originally, it was thought that NADPH oxidase existed only in phagocytic cells to protect the
… NOX1, originally discovered using Caco-2 human colon cancer cells, is expressed in both …

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

M Ushio-Fukai, Y Nakamura - Cancer letters, 2008 - Elsevier
… from this oxidase are involved in … NADPH oxidase and redox signaling events involved in
angiogenesis. Understanding these mechanisms may provide insight into the NADPH oxidase

NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicity

R Paletta-Silva, N Rocco-Machado… - International journal of …, 2013 - mdpi.com
… are all NADPH-derived ROS sensitive. Our goal in this review is to discuss the mechanisms
by which NADPH oxidase … of cancer, and the role of NADPH oxidase in the mechanisms of …

NADPH Oxidase 4 (NOX4) in cancer: linking redox signals to oncogenic metabolic adaptation

I Szanto - International Journal of Molecular Sciences, 2022 - mdpi.com
Cancer cells can survive and maintain their high proliferation … cellular ROS sources is the
NADPH oxidase enzymes (NOX-es). … in the oncogenic metabolic adaptation of cancer cells. …

NADPH Oxidases NOXs and DUOXs as putative targets for cancer therapy

U Weyemi, CE Redon, PR Parekh… - Anti-Cancer Agents …, 2013 - ingentaconnect.com
cancer (NOX1 and NOX5), melanoma and glioblastoma (NOX4) among others. In addition,
recent studies reveal that targeting NADPH oxidases … strategies to fight cancer. This review …

Molecular insights of NADPH oxidases and its pathological consequences

BN Waghela, FU Vaidya, Y Agrawal… - Cell biochemistry …, 2021 - Wiley Online Library
… types of cancers is an emerging interest in the field of cancer research… cancer cells. It was
also observed that the knockdown of NOX-1 using shRNA in HT-29 cells (human colon cancer

NADPH oxidases: new actors in thyroid cancer?

R Ameziane-El-Hassani, M Schlumberger… - Nature Reviews …, 2016 - nature.com
… role of NADPH oxidases in thyroid pathophysiology, with a special emphasis on cancer. The
… While the role of NADPH oxidases in carcinogenesis is still hypothetical, their involvement …