… specificity of these NOX inhibitors are discussed. We conclude that NOX inhibition is a pertinent
… to develop specific NOX inhibitors suited for clinical application. Antioxid. Redox Signal. …

… inhibitors with low off-target effects. These works have led to the characterization of several
new potent NOX inhibitors… reviewing more than 25 known NOX inhibitors, focusing mainly on …

… specific NOX isoforms. Critical Issues: Here, we discuss whether novel NOX inhibitors enable
reliable validation of NOX isoforms… Modern NOX inhibitors have increased the evidence for …

… and function of NOX enzymes, their regulation, and the evidence linking NOX activity to
the pathogenesis of various diseases. We also discuss the various NOX inhibitors that have …

… isoforms of nonphagocytic NADPH oxidase. Endothelial cells, … now designated the Nox
family of NADPH oxidases and are … of NADPH oxidase and NADPH oxidase inhibitors in the …

… category of scavengers or inhibitors of more than one … inhibitors of NADPH oxidase over
the past decade, from the peptidic inhibitor Nox2ds-tat to more recent small molecule inhibitors …

… NADPH oxidase inhibitors, small molecule Nox inhibitors, peptides and siRNAs. Expert
opinion: Since each member of the NADPH oxidase … registered as NADPH oxidase inhibitors in …

… of “intelligent” Nox inhibitors plausible, which selectively … of NADPH oxidase activation and
therefore this article can only provide a small overview, covering the general principles of Nox …

… [62–66] have been published; we focus here on the first NADPH oxidase, but not isoform
selective inhibitor, VAS2870 and its analogue VAS3947. For a detailed overview of the other …

… We found that most of the tested NOX inhibitors have very substantial off-target … the NOX
targets. However, we also show that a few of the known NOX inhibitors are indeed proper NOX …