… This review focuses on advances in therapeutic peptide brain delivery … peptides) in treating
various systemic diseases. Additionally, this review briefly highlights the anatomy of the nasal …

… peptide and protein drugs by routes of administration other than by injection. Studies in this
area of drug delivery have included nasal, … augmentation with aerosol therapy consisting of y-…

… (approximately 180 cm 2 ) in the nasal cavity, the lung offers a large … aerosol drugs, including
proteins and peptides, within the respiratory tract is the particle characteristics of the aerosol…

… Peptides are rapidly being developed as potential new therapeutic agents and the nasal
route is being evaluated as a means of achieving systemic absorption. Current research in man …

… Formulation of proteins/peptides for therapeutic uses has often posed some challenges …
aerosol spray, which is directed by a suitable adaptor/actuator for administration via oral or nasal …

… deliver peptides to treat diseases outside the lung whose target is the systemic circulation
(systemic drug delivery). These newer applications for aerosol therapy are … A liquid nasal spray …

… constitute protein- or peptide-based therapies and are often … different biological-based
therapies for respiratory disease, … and nasal epithelial clone 1 (SPLUNC1)-derived peptides that …

… In the recent past, drug aerosol delivery devices for inhalable peptides and proteins have …
the long-term therapy. Currently, several peptide-based nasal formulations have entered the …

… A variety of nasal spray devices are available for peptide drug products, including single-
or multi-dose mechanical spray pumps, pressurized nasal aerosol spray pumps or nasal …

… [18] and can deliver various therapeutic agents, including macromolecules and small …
chronic therapy in patients [11,18]. This review focuses on advances in therapeutic peptide brain …