… ) and native small-molecule drugs by making use of cell-penetrating poly(disulfide)s (CPDs). …
for delivery of proteins and native small-molecule drugs have not been demonstrated. With …

… synthesis methods for poly(disulfide)s based on the … poly(disulfide)-based delivery systems
developed in recent years from a drug perspective, emphasizing both small-molecule drugs …

… The cell-penetrating poly (disulfide)(CPD) is an effective tool for intracellular delivery, as it
is taken up through thiol-mediated cellular uptake, thus avoiding endolysosomal entrapment …

… of disulfide linkage) and the release of the pendant drug. The cascade reaction involves GSH
trigger cleavage of the backbone disulfide … 1) producing the active drug in its native form. …

… native lysines on non-glycosylated proteins, followed by bioorthogonal conjugation with
cell-penetrating poly(disulfide)s (… of their “native” functional forms with immediate bioavailability. …

… The disulfide bond is a dynamic covalent bond, which can be … of disulfides accounts for
unique properties in poly(disulfide)s … Without disulfides in their main chain, neither proteins nor …

… that can render the native disulfide bond formation. Thus, while disulfide-containing small …
confirm the latent potential of disulfide bonds for enhancing drug-like profiles of peptide …

… d) Prodrug of taxoid (SB-T-1214) is activated inside tumor cells by endogenous thiols (eg,
GSH) to achieve native drug release, with the formation of five membered cyclic benzothiophen…

… Reductive depolymerization after cellular uptake should then release the native substrates …
poly(disulfide)s with covalently attached substrates in solution (Figure 1). Probes or drugs that …

… degradation profile of the poly(disulfide)-based nanonetwork … the redox-responsive
poly(disulfide) network degradation … shows multimodal distribution for the poly(disulfide)-based …