… sixty natural alkaloids … alkaloids are found with strong to moderate hCES2A inhibition
activity. Primary structure–activity relationships (SAR) analysis of natural isoquinoline alkaloids …

… Eserine, a natural alkaloid, was found to be a highly specific hCE2 inhibitor with the K i value
to be 0.358 μM (Table 7) [113]. Further investigation also found that eserine could potently …

… These biological activities are associated with the isoquinoline alkaloids hydrastine and
berberine. Liu … Identification and characterization of naturally occurring inhibitors against human …

… Physostigmine, a natural alkaloid, was a highly specific CES2 inhibitor with the Ki value of
0.358 μM [110]. Physostigmine potently inhibited the hydrolysis of irinotecan but did not affect …

… Human carboxylesterase 2 (CES2), one of the most … discover efficacious CES2 inhibitors
from natural products and to … potency of more than 100 natural products against CES2, it was …

… alkaloids using an established CES1 assay and incubation system. Three separate kratom
extracts and the major kratom alkaloids … screen mimicking alkaloid exposures in humans, a …

… borderline between alkaloids and naturally existing complex amines. Typical alkaloids are
… and putative NADPH-FMNreductase, carboxylesterase, CYP2B6, CYP3A4, and CYP2D6. …

… Natural products containing 1,2-diones Recently, two indole alkaloids have been identified
in extracts of marine organisms that contain the ethane-1,2-dione chemotype Citation[51,52]. …

… To discover the potential natural human carboxylesterase 2 (hCE 2) … Human carboxylesterases
(hCEs) are classified into two subtypes, human carboxylesterase 1 (hCE 1) and human …

… Aspidosperma and iboga alkaloids are plant-derived natural … through the action of homologous
carboxylesterase (CXE)-like … formation of the aspidosperma alkaloid scaffold. Key amino …