Molecular mechanisms of antiproliferative effects of natural chalcones

R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
… A plethora of molecular mechanisms of action have been documented, including induction
of … the basic molecular mechanisms related to the antiproliferative effects of chalcones, …

Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
… The purpose of this review is to summarize the most important pharmacological activities
highlighting the cellular and molecular mechanisms of action of natural and synthetic chalcones

Chalcones: Synthetic chemistry follows where nature leads

HA Jasim, L Nahar, MA Jasim, SA Moore, KJ Ritchie… - Biomolecules, 2021 - mdpi.com
… Some of those molecular mechanisms of activities of chalcones are discussed in the … the
ability of chalcones to induce Nrf2. The ability of synthetic and natural chalcones to activate the …

Two important anticancer mechanisms of natural and synthetic chalcones

T Constantinescu, AG Mihis - International Journal of Molecular Sciences, 2022 - mdpi.com
ATP-binding cassette subfamily G and tubulin pharmacological mechanisms decrease the
effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin …

Cellular and molecular mechanisms activating the cell death processes by chalcones: Critical structural effects

P Champelovier, X Chauchet, F Hazane-Puch… - Toxicology in Vitro, 2013 - Elsevier
Chalcones are naturally occurring compounds with diverse … Both chalcones increased
Bax/Bcl2 ratios and decreased Ki67 … of chalcones A and B, significant differences in mechanism of …

Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms

E Karimi-Sales, G Mohaddes, MR Alipour - Pharmacological research, 2018 - Elsevier
Chalcones form an important group of natural compounds and flavonoid precursors which
are abundant in fruits, vegetables, and edible plants. These compounds have many beneficial …

Anticancer activity of natural and synthetic chalcones

T Constantinescu, CN Lungu - International journal of molecular sciences, 2021 - mdpi.com
… DNA damage, especially to 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-nitroguanidine,
has been shown to be a molecular mechanism for cancer [11]. Cell apoptosis or programmed …

Molecular targeted approaches to cancer therapy and prevention using chalcones

DD Jandial, CA Blair, S Zhang, LS Krill… - Current cancer drug …, 2014 - ingentaconnect.com
… in proteins, some lead chalcones from both natural products and synthesis have been …
in chalcone structures can lead to significantly different molecular mechanisms for chalcone

Naturally occurring chalcones and their biological activities

Z Rozmer, P Perjési - Phytochemistry reviews, 2016 - Springer
naturally occurring chalcone compounds which have been isolated from different plants.
Chalcones … and biological activity of natural chalcones, describing 646 compounds have been …

Isolation and biological activity of natural chalcones based on antibacterial mechanism classification

S Wang, C Li, L Zhang, B Sun, Y Cui, F Sang - Bioorganic & Medicinal …, 2023 - Elsevier
… activity and mechanism. Therefore, this review focuses on the antibacterial activity and
mechanisms of seventeen natural chalcones. Firstly, seventeen natural chalcones have been …