… focused on the identified natural inhibitors and their inhibition potency against both hCE1 …
in use are derived from natural products or their mimics, while natural products will continue to …

… Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily.
In the human body, two predominant carboxylesterases (CES1 and CES2) have been …

… The inhibitory capacities and inhibition mechanism of a variety of carboxylesterases
inhibitors including synthetic, semi-synthetic and natural compounds are comprehensively …

… that widely used in many countries, while humans may be exposed to these toxins by … the
inhibitory effects of six commonly used pyrethroids against two major human carboxylesterases …

… of natural triterpenoids were collected and their inhibitory effects against human
carboxylesterases were … Finally, the compound BA was found to have a strong inhibitory effect on …

… selective inhibitors against hCE1 are rarely reported. This study aimed to assess the inhibitory
effects of natural flavonoids against hCE1 and to find potential specific hCE1 inhibitors. To …

… In humans, the majority of CEs belong to the CE1 and CE2 gene families, … human
carboxylesterase 1 (hCE1) and carboxylesterase 2 (hCE2) are the major CEs distributed in human …

… Results: The results showed that more than 50 natural inhibitors of CES1 or CES2, including
phenolic chemicals, triterpenoids, and tanshinones were found from herbs, whereas only …

… the inhibitory effects of the crude ethanol extract from FP on human carboxylesterase 2 (hCE2),
as well as to identity and characterize the naturally occurring inhibitors of hCE2 in …

… In this study, more than sixty natural alkaloids have been collected and their inhibitory …
hCES2A inhibition activity. Primary structure–activity relationships (SAR) analysis of natural …