Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.

JP Houchins, LL Lanier, EC Niemi… - … (Baltimore, Md.: 1950 …, 1997 - journals.aai.org
… either in activation or inhibition of NK cell cytolytic activity. Several members of the Ly-…
cytolytic activity of NK cells when engaged by an appropriate MHC class I molecule on a target cell

Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells.

ME Ostensen, DL Thiele, PE Lipsky - Journal of immunology …, 1987 - journals.aai.org
… able to modify the cytolytic activity of NK cells (3). Recently, it has … human natural killer cells
and natural killer-like cell line (YT cells)… on a natural killer-like cell line (YT cells). J . lmmunol. …

[HTML][HTML] Histone deacetylase inhibitors suppress natural killer cell cytolytic activity

H Ogbomo, M Michaelis, J Kreuter, HW Doerr… - FEBS letters, 2007 - Elsevier
Natural killer (NK) cells as components of the innate immunity substantially … activity of human
polyclonal NK cells treated with two HDACi, SAHA and VPA, on several leukemic cell lines. …

Demethylating treatment suppresses natural killer cell cytolytic activity

X Gao, J Lin, L Wang, L Yu - Molecular immunology, 2009 - Elsevier
… NK cell function. To test this speculation, we examined the cytolytic activity of NK-92MI cells
and polyclonal NK cells … the cytolytic activity of NK-92MI cell line and human polyclonal NK …

Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity

G Pietra, C Manzini, S Rivara, M Vitale, C Cantoni… - Cancer research, 2012 - AACR
… role in antitumor activity. NK cells are considered promising effector cells in the adoptive …
A high degree of natural cytolytic activity of peripheral blood (PB) lymphocytes has been …

The cytotoxic activity of human natural killer cells requires an intact secretory apparatus

O Carpén, I Virtanen, E Saksela - Cellular Immunology, 1981 - Elsevier
… of cellular secretion and motility on the cytolytic activity of human natural killer (NK) cells.
As … are required in the cytolytic activity of human NK cells. In the monensin-treated effector …

Human natural killer cell adhesion molecules. Differential expression after activation and participation in cytolysis.

MJ Robertson, MA Caligiuri, TJ Manley… - … (Baltimore, Md.: 1950 …, 1990 - journals.aai.org
cell lysis (18-20). We postulated that the regulation of NK cell cytolytic activity and the induction
of LAK activity … and cytolysis: their known ligands (CD54 and CD58) were also studied. …

Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19

M Osman, RM Faridi, W Sligl, MT Shabani-Rad… - Blood …, 2020 - ashpublications.org
… Here, we describe impaired NK-cell cytolytic activity associated with a loss of cytokines
important in NK-cell stimulation in severe COVID-19 patients. This impairment and the resulting …

Mechanisms of natural killer cell-mediated cellular cytotoxicity

I Prager, C Watzl - Journal of leukocyte biology, 2019 - academic.oup.com
… are the major mediators of this activity. Here, we summarize the cytotoxic mechanisms of
NK cells. NK cells can kill virally infected of transformed cells via the directed release of lytic …

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

AH Rook, JH Kehrl, LM Wakefield… - … (Baltimore, Md.: 1950 …, 1986 - journals.aai.org
… In this study, the effects of TGF-fl on natural killer (NK) cell function were investigated. After
20 hr of culture in the presence of TGF-B, the NK activity of peripheral blood lymphocytes (PBL…